In-vitro and in-vivo anti-inflammatory activity of Andrographis serpyllifolia (Rottl. Ex Vahl.) Wt.

Authors

  • Vasu Kandati Faculty of Pharmaceutical Sciences, JNTU, Hyderabad, Andhra Pradesh
  • P Govardhan Department of Pharmacology, Vaagdevi College of Pharmacy, Warangal-506001, Andhra Pradesh
  • Ch Siva Reddy Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh
  • A Ravinder Nath Department of Pharmacy, Osmania Universtiy, Hyderabad-500007, Andhra Pradesh
  • R R Reddy Arya College of Pharmacy, Kandi-502285, Sanga Reddy, Andhra Pradesh

DOI:

https://doi.org/10.3329/icpj.v1i8.11250

Keywords:

Andrographis serpyllifolia, anti-inflammatory, analgesic, 5-LOX, In-vivo animal models

Abstract

The study was aimed to evaluate the analgesic and anti-inflammatory activity (by both in-vitro and in-vivo) of both chloroform and methanol root extracts of Andrographis serpyllifolia (Rottl. Ex Vahl.) Wt. Methods used for the studies were In-vitro 5-Lipoxygenase inhibition assay and In-vivo measurement of rat paw edema and ear edema in rats, acetic acid induced writhing response and hot plate method in albino mice. Chloroform and methanolic extracts of A. serpyllifolia root have shown moderate potency in inhibiting 5-LOX and shown significant anti-inflammatory activity. Despite the IC50 values are little higher, anti-inflammatory efficacy of these extracts possibly due to other mechanisms apart of 5-LOX inhibition. However, In-vivo anti-inflammatory studies revealed that A. serpyllifolia methanolic extract has shown higher degree of efficacy when compared to the chloroform extract. In terms of analgesic activity in writhing test, methanolic extract has shown more efficacy than chloroform extract. Hence, it is important to isolate the active principles for further testing the anti-inflammatory efficacy.

DOI: http://dx.doi.org/10.3329/icpj.v1i8.11250

International Current Pharmaceutical Journal 2012, 1(8): 199-204

 

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Author Biography

Vasu Kandati, Faculty of Pharmaceutical Sciences, JNTU, Hyderabad, Andhra Pradesh

Arya College of Pharmacy, Kandi-502285, Sanga Reddy, Andhra Pradesh, INDIA

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Published

2012-07-05

How to Cite

Kandati, V., Govardhan, P., Reddy, C. S., Nath, A. R., & Reddy, R. R. (2012). In-vitro and in-vivo anti-inflammatory activity of Andrographis serpyllifolia (Rottl. Ex Vahl.) Wt. International Current Pharmaceutical Journal, 1(8), 199–204. https://doi.org/10.3329/icpj.v1i8.11250

Issue

Vol. 1 No. 8 (2012)

Section

Original Articles

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