Hepatoprotective activity of Adina cordifolia against ethanol induce hepatotoxicity in rats

Authors

  • A Sharma Research Scholar, Department of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan
  • B Sangameswaran Principal, SSM College of Pharmacy, Jambai Village, Bhavani Taluk, Erode-638 312, Tamil Nadu
  • V Jain TIT College of Pharmacy, Bhopal
  • M S Saluja Research Scholar, Department of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan

DOI:

https://doi.org/10.3329/icpj.v1i9.11619

Keywords:

Silymarin, SGOT, SGPT, alkaline phosphate, total bilirubin, total protein

Abstract

The acetone (AEAC) and aqueous extracts (AQEAC) of Adina cordifolia, belonging to the family Rubiaceae, were studied for hepatoprotective activity against Wister rats with liver damage induced by ethanol. It was found that AEAC and AQEAC, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent and also significantly increased the levels of total protein. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of ethanol treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by ethanol and blood samples from the animals treated with AEAC and AQEAC showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells against ethanol induced hepatocellular injury. The effects of AEAC and AQEAC were comparable with standard drug silymarin.

DOI: http://dx.doi.org/10.3329/icpj.v1i9.11619

International Current Pharmaceutical Journal 2012, 1(9): 279-284

 

Downloads

Download data is not yet available.
Abstract
136
PDF
81

Downloads

Published

2012-08-04

How to Cite

Sharma, A., Sangameswaran, B., Jain, V., & Saluja, M. S. (2012). Hepatoprotective activity of Adina cordifolia against ethanol induce hepatotoxicity in rats. International Current Pharmaceutical Journal, 1(9), 279–284. https://doi.org/10.3329/icpj.v1i9.11619

Issue

Vol. 1 No. 9 (2012)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).