Development of RP-HPLC method for the estimation of Rasagiline mesylate in bulk and tablet dosage forms

Authors

  • Napa Delhi Raj Nimra college of Pharmacy, Nimra nagar, Jupudi-521456, Vijayawada, Krishna (Dt), Andhra Pradesh
  • Abburu Rukmangada Rao Nimra college of Pharmacy, Nimra nagar, Jupudi-521456, Vijayawada, Krishna (Dt), Andhra Pradesh
  • Chusena Narasimharaju Bhimanadhuni Department of Pharmaceutical Analysis, Annabattuni Satya Narayana Pharmacy College, Burripalem Road, Tenali-522201, Guntur (Dt), Andhra Pradesh

DOI:

https://doi.org/10.3329/icpj.v1i9.11620

Keywords:

Rasagiline, Purosphere star RP-18, Tablets, Estimation, RP-HPLC, Validation, Method development

Abstract

A simple RP-HPLC method for the determination of Rasagiline Mesylate in bulk and tablet dosage form was developed. Numerous HPLC conditions were tested for determination of rasagiline. The best result was achieved by using Purosphere star RP-18, (150×4.6mm), 5µm column and a mobile phase consisting of Potassium Orthophosphate: Acetonitrile (60:40 v/v) adjusted to pH 7.0(±0.05) with Ammonia solution, a flow rate of 1.5 ml/min with ultraviolet detection at 210nm. The correlation coefficients for calibration curves within the detection range of 5-30µg/ml were 0.9993. The within and between-day precision was determined for both retention time and peak area. The retention time of rasagiline is 6.0 minutes.

DOI: http://dx.doi.org/10.3329/icpj.v1i9.11620

International Current Pharmaceutical Journal 2012, 1(9): 285-287

 

Downloads

Download data is not yet available.
Abstract
150
PDF
79

Downloads

Published

2012-08-04

How to Cite

Raj, N. D., Rao, A. R., & Bhimanadhuni, C. N. (2012). Development of RP-HPLC method for the estimation of Rasagiline mesylate in bulk and tablet dosage forms. International Current Pharmaceutical Journal, 1(9), 285–287. https://doi.org/10.3329/icpj.v1i9.11620

Issue

Vol. 1 No. 9 (2012)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).