Development of RP-HPLC method for the estimation of Rasagiline mesylate in bulk and tablet dosage forms

Authors

  • Napa Delhi Raj Nimra college of Pharmacy, Nimra nagar, Jupudi-521456, Vijayawada, Krishna (Dt), Andhra Pradesh
  • Abburu Rukmangada Rao Nimra college of Pharmacy, Nimra nagar, Jupudi-521456, Vijayawada, Krishna (Dt), Andhra Pradesh
  • Chusena Narasimharaju Bhimanadhuni Department of Pharmaceutical Analysis, Annabattuni Satya Narayana Pharmacy College, Burripalem Road, Tenali-522201, Guntur (Dt), Andhra Pradesh

DOI:

https://doi.org/10.3329/icpj.v1i9.11620

Keywords:

Rasagiline, Purosphere star RP-18, Tablets, Estimation, RP-HPLC, Validation, Method development

Abstract

A simple RP-HPLC method for the determination of Rasagiline Mesylate in bulk and tablet dosage form was developed. Numerous HPLC conditions were tested for determination of rasagiline. The best result was achieved by using Purosphere star RP-18, (150×4.6mm), 5µm column and a mobile phase consisting of Potassium Orthophosphate: Acetonitrile (60:40 v/v) adjusted to pH 7.0(±0.05) with Ammonia solution, a flow rate of 1.5 ml/min with ultraviolet detection at 210nm. The correlation coefficients for calibration curves within the detection range of 5-30µg/ml were 0.9993. The within and between-day precision was determined for both retention time and peak area. The retention time of rasagiline is 6.0 minutes.

DOI: http://dx.doi.org/10.3329/icpj.v1i9.11620

International Current Pharmaceutical Journal 2012, 1(9): 285-287

 

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Published

2012-08-04

How to Cite

Raj, N. D., Rao, A. R., & Bhimanadhuni, C. N. (2012). Development of RP-HPLC method for the estimation of Rasagiline mesylate in bulk and tablet dosage forms. International Current Pharmaceutical Journal, 1(9), 285–287. https://doi.org/10.3329/icpj.v1i9.11620

Issue

Vol. 1 No. 9 (2012)

Section

Original Articles

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