Formulation and evaluation of colon specific microbial degradable matrix tablet using sterculia gum as carrier

Authors

  • M Mallikarjuna Gouda Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka
  • A Ramakrishna Shabaraya Department of Pharmaceutics, Srinivas College of Pharmacy, Mangalore, Karnataka
  • S M Shanta Kumar Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, Karnataka

DOI:

https://doi.org/10.3329/icpj.v1i11.12064

Keywords:

Ciprofloxacin HCl, Carbopol 934 P, Ethyl Cellulose, Wet granulation, Rat cecal content, Irritable bowel disease

Abstract

Current study is to develop the colon targeted matrix tablet using the natural polysaccharide sterculia gum as carrier and model drug ciprofloxacin HCl. The matrix tablets were prepared by wet granulation technology using the various proportions of sterculia gum with carbopol 934 P, sterculia gum and ethyl cellulose polymer blends. Granules of all formulations were evaluated for rheological, post compressional properties and in vitro dissolution study in different pH buffers of pH 1.2 , pH 7.4 , pH 6.8 (saline phosphate buffer) without and with 4% rat cecal content in order to mimic GIT condition . Formulation SGC2 to SGC4 and SGE7 to SGE9 has released 13.6% to 38.9% in the initial 5h and released more amount of drug in stomach and small intestine than colon. Formulation SGC5 containing 45% of sterculia gum and 25% carbopol 934 p and Formulation SGE10 containing 45% of sterculia gum and 25% ethyl cellulose has released minimum 10.91 % to 13.04 % in the initial 5h and sustained the drug release up to 24 h and at the end of study released 75% to 79.99%. Formulations with 4% rat cecal content at the end of 24 h study drug released is 90.44% to 95.33% indicating higher amount of drug release is due to enzymatic break down of sterculia gum in the matrix tablet. Hence the above results conclude that the formulation SGC5 and SGE10 are potential in targeting the drug to colon to treat irritable bowel disease.

DOI: http://dx.doi.org/10.3329/icpj.v1i11.12064

International Current Pharmaceutical Journal 2012, 1(11): 376-383

Downloads

Download data is not yet available.
Abstract
563
PDF
566

Downloads

Published

2012-10-03

How to Cite

Gouda, M. M., Shabaraya, A. R., & Kumar, S. M. S. (2012). Formulation and evaluation of colon specific microbial degradable matrix tablet using sterculia gum as carrier. International Current Pharmaceutical Journal, 1(11), 376–383. https://doi.org/10.3329/icpj.v1i11.12064

Issue

Vol. 1 No. 11 (2012)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).