Enhancing dissolution profile of diazepam using hydrophilic polymers by solid dispersion technique

Authors

  • Md. Sariful Islam Howlader Department of Pharmacy, World University of Bangladesh, Dhanmondi, Dhaka 1205
  • Jayanta Kishor Chakrabarty Department of Pharmacy, Northern University of Bangladesh, Kazi Nazrul Islam Avenue, Dhaka-1215
  • Khandokar Sadique Faisal Department of Pharmacy, Northern University of Bangladesh, Kazi Nazrul Islam Avenue, Dhaka-1215
  • Uttom Kumar Faculty of Pharmacy, University of Dhaka, Dhaka 1000
  • Md. Raihan Sarkar Faculty of Pharmacy, University of Dhaka, Dhaka 1000
  • Mohammad Firuz Khan Faculty of Pharmacy, University of Dhaka, Dhaka 1000

DOI:

https://doi.org/10.3329/icpj.v1i12.12453

Keywords:

Molecular dispersion, hydrophilic polymer, SEM, Solvent evaporation technique, gamma-aminobutyric acid

Abstract

The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Diazepam was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxamer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37°C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure Diazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. SEM (Scanning Electron microscope) studies shows that the solid dispersion having a uniform dispersion. Solid dispersions prepared with PEG-6000, Poloxamer showed the highest improvement in wettability and dissolution rate of Diazepam. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, Diazepam.

DOI: http://dx.doi.org/10.3329/icpj.v1i12.12453

International Current Pharmaceutical Journal 2012, 1(12): 423-430

Downloads

Download data is not yet available.
Abstract
180
PDF
421

Downloads

Published

2012-11-01

How to Cite

Howlader, M. S. I., Chakrabarty, J. K., Faisal, K. S., Kumar, U., Sarkar, M. R., & Khan, M. F. (2012). Enhancing dissolution profile of diazepam using hydrophilic polymers by solid dispersion technique. International Current Pharmaceutical Journal, 1(12), 423–430. https://doi.org/10.3329/icpj.v1i12.12453

Issue

Vol. 1 No. 12 (2012)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).