Phytochemical and pharmacological evaluations of Polygonum lapathifolium stem extract for anthelmintic and antiemetic activity
DOI:
https://doi.org/10.3329/icpj.v2i3.13582Keywords:
Polygonum lapathifolium, Pheretima posthuma, piperizine citrate, chick, metoclopramide, copper sulphateAbstract
The present study is an attempt to preliminary phytochemical investigation, anthelmintic and anti-emetic activity studies on methanolic extract of Polygonum lapathifolium stems. The phytochemical screening shows the presence of phytosterols, diterpens, amino acid & protein, alkaloid and flavonoids, those are responsible for antiviral, antibacterial, antiallergic, antihypertensive, antiarrythmic, hepatoprotective, anti-inflammatory effects in mammals. In Anthelmintic activity test (using Pheretima posthuma model) five concentrations (20, 40, 60, 80 and 100 mg/ml in distilled water) of extracts were used which involved the determination of time of paralysis (vermifuge) and time of death (vermicidal activity) of the worms, where the concentration of 60, 80 &100 mg/ml showed a significant anthelmintic activity. Observations were comparable with the standard drug at concentration of 10mg/ml of piperizine citrate. On the other hand, in anti-emetic test, emesis was induced by the oral administration of copper sulphate 50mg/kg body weight to four days age of young chicks using chick emesis model. The antiemetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control disorders. The extracts (150 mg /kg orally) showed statistically significant antiemetic effect (90.45% Inhibition) compared with reference drug metoclopramide (50mg/kg intraperitoneally) which showed 82.48% Inhibition. From these observations, it was concluded that stems extracts have potential anthelmintic and anti-emetic properties. The plant may further be explored for its various pharmacological activities.
DOI: http://dx.doi.org/10.3329/icpj.v2i3.13582
International Current Pharmaceutical Journal, February 2013, 2(3): 57-62
Downloads
149
65
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).