Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor

Authors

  • Prameela Rani Avula Department of Pharmaceutics University College of Pharmaceutical Sciences Acharya Nagarjuna University Guntur -522510
  • Hema Veesam Department of Pharmacy KVSR Siddhartha College of Pharmaceutical Sciences Vijayawada-520010

DOI:

https://doi.org/10.3329/icpj.v2i7.15153

Keywords:

Oxcarbazepine, granules, factorial design, flow properties, dissolution

Abstract

As traditional drug delivery poses many disadvantages such as difficulty in consumption, the granules were opted to replace tablet dosage forms available in the market. A 23 full factorial design was employed for the formulation and characterization of the granule dosage form of oxcarbazepine. From regression equations we can assess the impact of each factor on the response further contour plots helped to pre-analyze the desired target factor values, in addition optimization process helped to analyze the values of dependent variables. Thus as of the results achieved a preferred response of flow property and drug release was obtained. In the current study, an attempt has been made to minimize possible number of experiments in the formulation of granule dosage forms. Polyvidone is a hydrophilic binder and primellose is a good disintegrate to obtain higher dissolution rate. A part, microwave assisted drying process plays a major role in achieving desired flow properties of granules.

DOI: http://dx.doi.org/10.3329/icpj.v2i7.15153

International Current Pharmaceutical Journal, June 2013, 2(7): 115-118

Downloads

Download data is not yet available.
Abstract
121
PDF
47

Downloads

Published

2013-06-01

How to Cite

Avula, P. R., & Veesam, H. (2013). Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor. International Current Pharmaceutical Journal, 2(7), 115–118. https://doi.org/10.3329/icpj.v2i7.15153

Issue

Vol. 2 No. 7 (2013)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).