Anti-inflammatory and antipyretic activity of Fioria vitifolia

Authors

  • Krishnamoorthi Mahalakshmi Prist University Tanjore, Tamil Nadu
  • Senthil Kumar Natesan JKKMMRF College of pharmacy Komarapalayam, Namakkal Tamil Nadu
  • Kugalur ganesan Parthiban JKKMMRF College of pharmacy Komarapalayam, Namakkal Tamil Nadu
  • Ganesan Sekar JKKMMRF College of pharmacy Komarapalayam, Namakkal Tamil Nadu

DOI:

https://doi.org/10.3329/icpj.v2i7.15154

Keywords:

Carrageenan, Malvacae, rat paw oedema, diclofenac, ethnicuses, Fioria vitifolia

Abstract

Fioria vitifolia Linn., (Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also as an immune system booster. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant. In the present study, the methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) and anti-pyretic (brewers yeast induced pyrexia) activities. Pre-treatment with the extract (250-500mg/ kg, p. o) significantly prevented increase in volume of paw oedema in dose dependent manner. A maximal effect was observed at 500mg/kg which was comparable to diclofenac (20mg/kg, orally). Ceiling effect at the dose of 500mg/kg was observed. The anti-pyretic effect of MEFV (measured as % reduction in body temperature) was compared with paracetamol (150mg/kg, orally). MEFV in dose of 500mg/kg caused significant decrease in body temperature of rats. In conclusion, this study has established the anti-inflammatory activity and anti pyretic activity of Fioria vitifolia and thus, justifies the ethnicuses of the plant.

DOI: http://dx.doi.org/10.3329/icpj.v2i7.15154

International Current Pharmaceutical Journal, June 2013, 2(7): 119-121

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Published

2013-06-01

How to Cite

Mahalakshmi, K., Natesan, S. K., Parthiban, K. ganesan, & Sekar, G. (2013). Anti-inflammatory and antipyretic activity of Fioria vitifolia. International Current Pharmaceutical Journal, 2(7), 119–121. https://doi.org/10.3329/icpj.v2i7.15154

Issue

Vol. 2 No. 7 (2013)

Section

Original Articles

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