Gastroretentive drug delivery system of a lipid lowering agent

Authors

  • D. Krishnarajan Department of Pharmaceutics JKK Munirajah Medical Research Foundation College of Pharmacy Ethirmedu, B.Komarapalaym Namakkal-638183, Tamilnadu
  • N. Senthil Kumar Department of Pharmaceutical Chemistry JKK Munirajah Medical Research Foundation College of Pharmacy Ethirmedu, B.Komarapalaym Namakkal- 638183, Tamilnadu
  • Rajesh Yadav Department of Pharmacy Sunrise Univercity, Alwar Rajasthan-301030

DOI:

https://doi.org/10.3329/icpj.v2i9.16077

Keywords:

Simvastatin, Mucoadhesive, Carbopal-934, Gastric residence time, swelling characters

Abstract

The objective of this study was to develop mucoadhesive tablets of Simvastatin using natural polymers. Simvastatin has short biological half-life and high first pass metabolism hence which was designed to increase the gastric residence time which prolong the drug release. The tablets were prepared by wet granulation technique using Carbopol-934, guar gum, xanthine gum and chitosin as polymers. Formulations were evaluated for different parameters like hardness, friability, uniformity of weight, swelling characteristics, in vitro dissolution and kinetic studies. The dissolution was carried out for 12 hours in which the formulation with guar gum has shown highest dissolution release profile (F9). Thus the present study concludes that mucoadhesive tablets of simvastatin can be a good way to pass the extensive hepatic first pass metabolism and to improve the bioavailability of simvastatin.

DOI: http://dx.doi.org/10.3329/icpj.v2i9.16077

International Current Pharmaceutical Journal, August 2013, 2(9): 152-155

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Published

2013-08-04

How to Cite

Krishnarajan, D., Kumar, N. S., & Yadav, R. (2013). Gastroretentive drug delivery system of a lipid lowering agent. International Current Pharmaceutical Journal, 2(9), 152–155. https://doi.org/10.3329/icpj.v2i9.16077

Issue

Vol. 2 No. 9 (2013)

Section

Original Articles

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