Comparative effects of different fractions of crude aqueous extract of Ficus exasperata leaves on blood pressure

Authors

  • Augustin Kouao Amonkan Laboratory of Nutrition and Pharmacology UFR-Biosciences Felix Houphouët-Boigny University 22 BP 582 Abidjan 22, Abidjan
  • André Brou Konan Laboratory of Nutrition and Pharmacology UFR-Biosciences Felix Houphouët-Boigny University 22 BP 582 Abidjan 22, Abidjan
  • Léandre Kouakou Kouakou Laboratory of Physiology Pharmacology and Phytotherapy UFR Sciences de la Nature Nangui Abrogoua University 02 BP 801 Abidjan 02, Abidjan
  • Mathieu Nahounou Bleyere Laboratory of Physiology Pharmacology and Phytotherapy UFR Sciences de la Nature Nangui Abrogoua University 02 BP 801 Abidjan 02, Abidjan
  • Marcel Guy Kouamé Bouafou Division of Life and Earth Sciences Department of Sciences and Technology Ecole Normale Superieure (ENS) 25 BP 663 Abidjan 25, Abidjan
  • Séraphin Kati-Coulibaly Laboratory of Nutrition and Pharmacology UFR-Biosciences Felix Houphouët-Boigny University 22 BP 582 Abidjan 22, Abidjan

DOI:

https://doi.org/10.3329/icpj.v2i11.16534

Keywords:

Blood pressure, hypotension, phytochemical compounds

Abstract

Ficus exasperata has been extensively used in folk medicine for the treatment of many ailments. The aqueous extract of leaves of this herb reduced blood pressure through its cholinomimetic effect. In this study, different fractions of the crude extract of F. exasperata leaves (FEFIX) were evaluated on blood pressure. Fractionated extracts were obtained by successive use of different solvents on the total crude extract. Phytochemical analysis was performed for each fraction and increasing doses (0.25 to 40 mg / kg b.w.) were administered intravenously. The phytochemical screening showed that alkaloids and phenols were found in ethanol fraction (FE-FEFIX) and methanol fraction (FM-FEFIX). Saponins and tannins have been identified only in the aqueous fraction (FA-FEFIX). Decreases in blood pressure were 40.02 ± 3.08 mm Hg for the ethanol fraction (FE-FEFIX), 9.95 ± 2.09 mm Hg for the methanol fraction (FM-FEFIX) and 5.26 ± 1.46 mm Hg in the aqueous fraction (FA-FEFIX). Hypotension induced by ethanol fraction is found to be greater than those induced by the other two fractions. In conclusion, this study showed that the hypotensive effect of F. exasperata leaves was greater with its ethanol extract. Alkaloids and phenols present in this extract may be involved in the hypotensive effect.

DOI: http://dx.doi.org/10.3329/icpj.v2i11.16534

International Current Pharmaceutical Journal, October 2013, 2(11): 193-195

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Published

2013-10-08

How to Cite

Amonkan, A. K., Konan, A. B., Kouakou, L. K., Bleyere, M. N., Bouafou, M. G. K., & Kati-Coulibaly, S. (2013). Comparative effects of different fractions of crude aqueous extract of Ficus exasperata leaves on blood pressure. International Current Pharmaceutical Journal, 2(11), 193–195. https://doi.org/10.3329/icpj.v2i11.16534

Issue

Vol. 2 No. 11 (2013)

Section

Original Articles

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