Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat

Authors

  • Manuj Kr. Bharali Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh
  • Hage Konya Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh
  • Luk Bahadur Chetry Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh

DOI:

https://doi.org/10.3329/icpj.v3i2.17511

Keywords:

ALT, AST, LPO, hepatotoxicity, AMBEOI, traditional medicine

Abstract

Acetaminophen (APAP) is a common antipyretic drug and leads to liver failure at over dose. In this study, the hepatoprotective effect of Aqueous Methanolic Bark Extract of Oroxylum indicum (L.)Vent. (AMBEOI) has been evaluated in rat model. Rats were treated with 1000 mgkg?1 body weight of APAP alone or with AMBEOI (10, 50 and 100 mgkg?1). Serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lipid peroxidation (LPO) in liver tissues were estimated 24 hrs after APAP and AMBEOI treatment. AMBEOI administration effectively reduced serum level of ALT and AST released from liver cells when compared to APAP treated group. AMBEOI also inhibited production of LPO in the liver tissues of APAP treated rats. Histopathological examination of liver samples revealed reduced necrotic areas in AMBEOI treated APAP group compared to APAP alone treated group. Together, this study confirmed the hepatoprotective activities of AMBEOI in APAP induced liver damage in rat.

DOI: http://dx.doi.org/10.3329/icpj.v3i2.17511

International Current Pharmaceutical Journal, January 2014, 3(2): 223-227

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Published

2014-01-02

How to Cite

Bharali, M. K., Konya, H., & Chetry, L. B. (2014). Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat. International Current Pharmaceutical Journal, 3(2), 223–227. https://doi.org/10.3329/icpj.v3i2.17511

Issue

Vol. 3 No. 2 (2014)

Section

Original Articles

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