Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat

Authors

  • Manuj Kr. Bharali Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh
  • Hage Konya Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh
  • Luk Bahadur Chetry Cell and Molecular Biology Section Department of Zoology Rajiv Gandhi University Rono Hills, Doimukh: 791112 Arunachal Pradesh

DOI:

https://doi.org/10.3329/icpj.v3i2.17511

Keywords:

ALT, AST, LPO, hepatotoxicity, AMBEOI, traditional medicine

Abstract

Acetaminophen (APAP) is a common antipyretic drug and leads to liver failure at over dose. In this study, the hepatoprotective effect of Aqueous Methanolic Bark Extract of Oroxylum indicum (L.)Vent. (AMBEOI) has been evaluated in rat model. Rats were treated with 1000 mgkg?1 body weight of APAP alone or with AMBEOI (10, 50 and 100 mgkg?1). Serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lipid peroxidation (LPO) in liver tissues were estimated 24 hrs after APAP and AMBEOI treatment. AMBEOI administration effectively reduced serum level of ALT and AST released from liver cells when compared to APAP treated group. AMBEOI also inhibited production of LPO in the liver tissues of APAP treated rats. Histopathological examination of liver samples revealed reduced necrotic areas in AMBEOI treated APAP group compared to APAP alone treated group. Together, this study confirmed the hepatoprotective activities of AMBEOI in APAP induced liver damage in rat.

DOI: http://dx.doi.org/10.3329/icpj.v3i2.17511

International Current Pharmaceutical Journal, January 2014, 3(2): 223-227

Downloads

Download data is not yet available.
Abstract
195
PDF
105

Downloads

Published

2014-01-02

How to Cite

Bharali, M. K., Konya, H., & Chetry, L. B. (2014). Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat. International Current Pharmaceutical Journal, 3(2), 223–227. https://doi.org/10.3329/icpj.v3i2.17511

Issue

Vol. 3 No. 2 (2014)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).