Effect of various extracts of Tabernaemontana divaricata on haloperidol induced catalepsy in rats

Authors

  • Chanchal N. Raj Department of Pharmacy Karpagam University,Coimbatore Tamilnadu, ? 641021
  • A. Balasubramaniam Technocrats Institute of Technology- Pharmacy Bhopal, M.P.-462021
  • Sayyed Nadeem Technocrats Institute of Technology- Pharmacy Bhopal, M.P.-462021

DOI:

https://doi.org/10.3329/icpj.v3i3.17891

Keywords:

Tabernaemontana divaricata, Parkinson’s disease (PD), catalepsy, haloperidol, bar test

Abstract

Parkinsons disease (PD) is one of the neurodegenerative diseases with selective loss of dopamine neurons of the substantia nigra pars compacta. In the present study, anti-cataleptic activity of Tabernaemontana divaricata leaves extracts viz. aqueous and ethanolic at different doses (50, 100 and 150 mg/kg i.p.) were studied using haloperidol (1 mg/kg, i.p.) induced catalepsy in rats which is a useful animal model for screening drugs for Parkinsons disease. Both the extracts were found to reduce catalepsy significantly (P<0.001) as compared to the haloperidol treated rats showing greater effect at 150 mg/kg i.p. dose. Thus the present study reveals the anti-cataleptic activity of Tabernaemontana divaricata evaluating the traditional folklore medicinal use of the plant.

DOI: http://dx.doi.org/10.3329/icpj.v3i3.17891

International Current Pharmaceutical Journal, February 2014, 3(3): 240-242

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Published

2014-02-05

How to Cite

Raj, C. N., Balasubramaniam, A., & Nadeem, S. (2014). Effect of various extracts of Tabernaemontana divaricata on haloperidol induced catalepsy in rats. International Current Pharmaceutical Journal, 3(3), 240–242. https://doi.org/10.3329/icpj.v3i3.17891

Issue

Vol. 3 No. 3 (2014)

Section

Original Articles

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