Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R

Authors

  • Irfan Bashir College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Ayesha Sethi College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Muhammad Zaman Faculty of Pharmacy The University of Lahore 54000 Lahore
  • Junaid Qureshi College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Rai M. Sarfraz Faculty of Pharmacy The Islamia University of Bahawalpur 63100 Bahawalpur
  • Asif Mahmood
  • Muhammad I. Sajid Faculty of Pharmacy University of Central Punjab Lahore 54000 Lahore
  • Talha Jamshaid University of Lyon
  • Muhammad A. Akram Faculty of Pharmacy University of Sargodha 40100 Sargodha

DOI:

https://doi.org/10.3329/icpj.v3i6.18761

Keywords:

Verapamil hydrochloride, Calan SR, kinetic models, matrix tablets, natural polymers.

Abstract

The purpose of the current work was to formulate Verapamil Hydrochloride (VH) sustained release matrix tablets by using natural polymers and comparison with leading national brand Calan SR of Searle Pharmaceuticals. Tragacanth and pectin were used in various concentrations. Pre compression studies i.e. angle of repose, bulk density, tapped density, Carrs compressibility index and Hausners ratio were also performed and found within the Pharmacopoeial limits. Eight formulations (F1-F8) of (VH) were prepared by direct compression method. Post compression studies i.e. Thickness, Hardness, Diameter, Friability and Dissolution studies were conducted. Different kinetic models i.e. zero order, first order, Highuchi model and Korsmeyer Peppas were applied to study release patterns and similarity index was calculated. Dissolution studies were carried out in phosphate buffer of pH 6.8 showed that formulations (F4 and F8) formulated with higher polymers concentration showed comparatively better drug retardation. F5 was the most comparable with the reference product. Verapamil hydrochloride released was observed non-fickian as diffusion following Higuchi model.

DOI: http://dx.doi.org/10.3329/icpj.v3i6.18761

International Current Pharmaceutical Journal, May 2014, 3(6): 286-290

Downloads

Download data is not yet available.
Abstract
227
PDF
183

Author Biography

Irfan Bashir, College of Pharmacy GC University of Faisalabad 38000 Faisalabad

Faculty of Pharmacy

University of Central Punjab Lahore 54000

Lahore

Downloads

Published

2014-05-03

How to Cite

Bashir, I., Sethi, A., Zaman, M., Qureshi, J., Sarfraz, R. M., Mahmood, A., Sajid, M. I., Jamshaid, T., & Akram, M. A. (2014). Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R. International Current Pharmaceutical Journal, 3(6), 286–290. https://doi.org/10.3329/icpj.v3i6.18761

Issue

Vol. 3 No. 6 (2014)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).