Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R

Authors

  • Irfan Bashir College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Ayesha Sethi College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Muhammad Zaman Faculty of Pharmacy The University of Lahore 54000 Lahore
  • Junaid Qureshi College of Pharmacy GC University of Faisalabad 38000 Faisalabad
  • Rai M. Sarfraz Faculty of Pharmacy The Islamia University of Bahawalpur 63100 Bahawalpur
  • Asif Mahmood
  • Muhammad I. Sajid Faculty of Pharmacy University of Central Punjab Lahore 54000 Lahore
  • Talha Jamshaid University of Lyon
  • Muhammad A. Akram Faculty of Pharmacy University of Sargodha 40100 Sargodha

DOI:

https://doi.org/10.3329/icpj.v3i6.18761

Keywords:

Verapamil hydrochloride, Calan SR, kinetic models, matrix tablets, natural polymers.

Abstract

The purpose of the current work was to formulate Verapamil Hydrochloride (VH) sustained release matrix tablets by using natural polymers and comparison with leading national brand Calan SR of Searle Pharmaceuticals. Tragacanth and pectin were used in various concentrations. Pre compression studies i.e. angle of repose, bulk density, tapped density, Carrs compressibility index and Hausners ratio were also performed and found within the Pharmacopoeial limits. Eight formulations (F1-F8) of (VH) were prepared by direct compression method. Post compression studies i.e. Thickness, Hardness, Diameter, Friability and Dissolution studies were conducted. Different kinetic models i.e. zero order, first order, Highuchi model and Korsmeyer Peppas were applied to study release patterns and similarity index was calculated. Dissolution studies were carried out in phosphate buffer of pH 6.8 showed that formulations (F4 and F8) formulated with higher polymers concentration showed comparatively better drug retardation. F5 was the most comparable with the reference product. Verapamil hydrochloride released was observed non-fickian as diffusion following Higuchi model.

DOI: http://dx.doi.org/10.3329/icpj.v3i6.18761

International Current Pharmaceutical Journal, May 2014, 3(6): 286-290

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Author Biography

Irfan Bashir, College of Pharmacy GC University of Faisalabad 38000 Faisalabad

Faculty of Pharmacy

University of Central Punjab Lahore 54000

Lahore

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Published

2014-05-03

How to Cite

Bashir, I., Sethi, A., Zaman, M., Qureshi, J., Sarfraz, R. M., Mahmood, A., Sajid, M. I., Jamshaid, T., & Akram, M. A. (2014). Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R. International Current Pharmaceutical Journal, 3(6), 286–290. https://doi.org/10.3329/icpj.v3i6.18761

Issue

Vol. 3 No. 6 (2014)

Section

Original Articles

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