Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya

Authors

  • Khaled Salem Alsalhen Department of Chemistry Sciences College Omar Al-Mukhtar University El-beida
  • Rahab Dawood Abdalsalam Department of Chemistry Sciences College Omar Al-Mukhtar University El-beida

DOI:

https://doi.org/10.3329/icpj.v3i7.19077

Keywords:

Malondialdehyde, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, triglycerides

Abstract

Tobacco use is widely spread throughout the world. The effect of smoking on human health are serious and in many cases, deadly. The present study was done to investigate the effect of cigarette smoking on some liver functions in male population in El-beida city, Libya. The study was carried out on thirty Libyan male smokers, who smoked at least 10 cigarettes per day for at least15 years. The group includes smokers with age range between 30-60 years. Non-smokers, (control, n= 30) group were collected with the same range of age for statistical comparison. The whole blood samples were drawn by venipuncture from each member and liver functions test were estimated by a kit method on automatic analyzer (Beckman BUN analyzer, USA). The results of the study revealed a significant increase of malondialdehyde (MDA), which is an indicator of lipid peroxidation and oxidative stress significantly increased in cigarette smokers in groups when compared with control group. While the plasma level of total protein, albumin and total bilirubin decreased during smoking. Cigarette smoking raised alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), plasma total cholesterol and triglycerides in smoker group when compared with non-smoker group. To conclude, cigarette smoking leads to oxidative stress by free radical generation by the mechanism of lipid peroxidation. Smoking exerts negative influence on liver functions test should be carefully interpreted, and further study on the mechanism of the effects is warranted.

DOI: http://dx.doi.org/10.3329/icpj.v3i7.19077

International Current Pharmaceutical Journal, June 2014, 3(7): 291-295

Downloads

Download data is not yet available.
Abstract
260
PDF
88

Downloads

Published

2014-06-07

How to Cite

Alsalhen, K. S., & Abdalsalam, R. D. (2014). Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya. International Current Pharmaceutical Journal, 3(7), 291–295. https://doi.org/10.3329/icpj.v3i7.19077

Issue

Vol. 3 No. 7 (2014)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).