Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions

Authors

  • Asma Ahmed Department of biochemistry Pir Mehr Ali Shah Arid Agriculture University Rawalpindi
  • Muahammad Javaid Asad Department of biochemistry Pir Mehr Ali Shah Arid Agriculture University Rawalpindi
  • Muhammad Sheeraz Ahmad Department of biochemistry Pir Mehr Ali Shah Arid Agriculture University Rawalpindi
  • Rehmatullah Qureshi Department of Botany Pir Mehr Ali Shah Arid Agriculture University Rawalpindi
  • Syed Imam Shah National Veterinary Laboratories PARK Road Islamabad
  • Hina Gul Department of Plant Sciences Faculty of Biological Sciences Quaid-i-Azam University, Islamabad
  • Muhammad Gulfraz Department of biochemistry Pir Mehr Ali Shah Arid Agriculture University Rawalpindi

DOI:

https://doi.org/10.3329/icpj.v4i2.21484

Keywords:

Anidiabetic, plant extract, fruit, leaves, Rhazya stricta Decne, polarity based extracts

Abstract

Diabetes mellitus is the most common human disease and there is growing interest for plant based therapy in managing diabetes mellitus specifically in the developing world. In the present study, Rhazya stricta Decne extract was analysed for its antidiabetic activities. Crude methanolic extracts of different plant parts were tested in vivo on albino mice Balb-C, for the reduction of blood glucose, urea, cholesterol, triacylglycerides and glycosylated haemoglobin. Results obtained showed that leaves of R. stricta have best antidiabetic effect by reducing blood glucose level, Glycosylated haemoglobin, triacylglycerides and Cholesterol in hyperglycaemic mice. The R. stricta leaves extract being most active was further fractionated by solvent extraction using n- Hexane, ethyl acetate, chloroform and water and all fractions were tested for same activities. It was found that ethyl acetate fraction is most effective in the reduction of blood glucose level at fasting and random conditions and blood glucose reduction was comparable to Glucophage, a standard antidiabetic drug. The present study suggests that Rhazya stricta leaves extract and its ethyl acetate fraction has great potential for development of antidiabetic drug.

DOI: http://dx.doi.org/10.3329/icpj.v4i2.21484

International Current Pharmaceutical Journal, January 2015, 4(2): 353-361

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Published

2015-01-07

How to Cite

Ahmed, A., Asad, M. J., Ahmad, M. S., Qureshi, R., Shah, S. I., Gul, H., & Gulfraz, M. (2015). Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions. International Current Pharmaceutical Journal, 4(2), 353–361. https://doi.org/10.3329/icpj.v4i2.21484

Issue

Vol. 4 No. 2 (2015)

Section

Original Articles

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