A comparative study for evaluating flurbiprofen effectiveness in postoperative pain

Authors

  • Ibrahim Dughaim Alreshidi Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R
  • Yu Feng Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R
  • Xie Han Nanjing Drum Tower Hospital Nanjing P.R

DOI:

https://doi.org/10.3329/icpj.v4i3.21935

Keywords:

Non-steroidal anti-inflammatory drugs, inflammatory pain, diclofenac, ketorolac, internal fixation of fracture, double-blind randomized study

Abstract

Aim of the present study was to evaluate the effect of flurbiprofen, which is a member of non-steroidal anti-inflammatory drug group (NSAIDs), on postoperative pain treatment. From September 2013 to May 2014, total of 250 patients were surveyed to perform a systematic evaluation of postoperative pain by comparing flurbiprofen with two other kinds of NSAIDs (diclofenac and ketorolac) and isotonic saline in a double-blind, randomized, placebo-controlled study. Patients were randomized for treatment: 65 cases received flurbiprofen, 60 cases received diclofenac sodium, 60 cases received ketorolac and 65 cases received the placebo (0.9% isotonic saline) (control group). After 24-hours of surgery patients treated with flurbiprofen, ketorolac, and diclofenac showed the lowermost PPI scores compared with those treated with 0.9% isotonic saline (P<0.05). Moreover, flurbiprofen-treated patients also had the lowest PRI(R)T scores (P<0.05). When the pain rating index was examined by subclass, a significantly lower PRI(R)S score was detected in the flurbiprofen group at 24 hours (P<0.05). However, at the 96-hour time point, no differences that were found in PPI and PRI[R] scores between the ketorolac, diclofenac, and flurbiprofen groups, whereas the control group was significantly less effective than the NSAID drugs. Flurbiprofen seemed to be the most effective NSAID for the treatment of pain after internal fixation of fracture, even though at 24 hours after surgery pain was at a maximum.

DOI: http://dx.doi.org/10.3329/icpj.v4i3.21935

International Current Pharmaceutical Journal, February 2015, 4(3): 367-369

 

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Author Biography

Ibrahim Dughaim Alreshidi, Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R

The Ministry of Higher Education

Saudi Arabia

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Published

2015-02-07

How to Cite

Alreshidi, I. D., Feng, Y., & Han, X. (2015). A comparative study for evaluating flurbiprofen effectiveness in postoperative pain. International Current Pharmaceutical Journal, 4(3), 367–369. https://doi.org/10.3329/icpj.v4i3.21935

Issue

Vol. 4 No. 3 (2015)

Section

Original Articles

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