A comparative study for evaluating flurbiprofen effectiveness in postoperative pain

Authors

  • Ibrahim Dughaim Alreshidi Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R
  • Yu Feng Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R
  • Xie Han Nanjing Drum Tower Hospital Nanjing P.R

DOI:

https://doi.org/10.3329/icpj.v4i3.21935

Keywords:

Non-steroidal anti-inflammatory drugs, inflammatory pain, diclofenac, ketorolac, internal fixation of fracture, double-blind randomized study

Abstract

Aim of the present study was to evaluate the effect of flurbiprofen, which is a member of non-steroidal anti-inflammatory drug group (NSAIDs), on postoperative pain treatment. From September 2013 to May 2014, total of 250 patients were surveyed to perform a systematic evaluation of postoperative pain by comparing flurbiprofen with two other kinds of NSAIDs (diclofenac and ketorolac) and isotonic saline in a double-blind, randomized, placebo-controlled study. Patients were randomized for treatment: 65 cases received flurbiprofen, 60 cases received diclofenac sodium, 60 cases received ketorolac and 65 cases received the placebo (0.9% isotonic saline) (control group). After 24-hours of surgery patients treated with flurbiprofen, ketorolac, and diclofenac showed the lowermost PPI scores compared with those treated with 0.9% isotonic saline (P<0.05). Moreover, flurbiprofen-treated patients also had the lowest PRI(R)T scores (P<0.05). When the pain rating index was examined by subclass, a significantly lower PRI(R)S score was detected in the flurbiprofen group at 24 hours (P<0.05). However, at the 96-hour time point, no differences that were found in PPI and PRI[R] scores between the ketorolac, diclofenac, and flurbiprofen groups, whereas the control group was significantly less effective than the NSAID drugs. Flurbiprofen seemed to be the most effective NSAID for the treatment of pain after internal fixation of fracture, even though at 24 hours after surgery pain was at a maximum.

DOI: http://dx.doi.org/10.3329/icpj.v4i3.21935

International Current Pharmaceutical Journal, February 2015, 4(3): 367-369

 

Downloads

Download data is not yet available.
Abstract
200
PDF
204

Author Biography

Ibrahim Dughaim Alreshidi, Department of Clinical Pharmacy China Pharmaceutical University Nanjing P.R

The Ministry of Higher Education

Saudi Arabia

Downloads

Published

2015-02-07

How to Cite

Alreshidi, I. D., Feng, Y., & Han, X. (2015). A comparative study for evaluating flurbiprofen effectiveness in postoperative pain. International Current Pharmaceutical Journal, 4(3), 367–369. https://doi.org/10.3329/icpj.v4i3.21935

Issue

Vol. 4 No. 3 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).