Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier

Authors

  • Md. Abu Shuaib Rafshanjani Department of Pharmacy Bangladesh University 15/1, Iqbal Road, Mohammadpur Dhaka-1207
  • Md. Mofizur Rahman Department of Pharmacy Bangladesh University 15/1, Iqbal Road, Mohammadpur Dhaka-1207
  • Shumaia Parvin Department of Pharmacy University of Rajshahi Rajshahi 6205
  • Md. Abdul Kader Department of Pharmacy University of Rajshahi Rajshahi 6205

DOI:

https://doi.org/10.3329/icpj.v4i10.24912

Keywords:

Glimepiride, solid lipid nano particles, dissolution rate, hot homogenization method, precipitation method

Abstract

Glimepiride is an antidiabetic drug of sulfonylurea group and indicated for the treatment of type 2 diabetes mellitus. The present study was conducted to enhance the dissolution rate of glimepiride solid lipid nano particle dispersions using hot homogenization method and glimepiride solid dispersion by precipitation method. Solid lipid nanoparticles have been used as suitable carriers for delivery of drug with poor solubility. In this investigation glyceryl monostearate and stearic acid were used as solid lipid, Lutrol F-68 as surfactant, Tween 80 as stabilizer and the used polymer were urea crystal and ?-cyclodextrin. Three formulations were prepared in different ratios for two methods and were designated as GMLN1 to GMLN3 in case of hot homogenization method and GMP1 to GMP3 for precipitation method. The evaluation of all the dispersions were done by in vitro dissolution studies using US Pharmacopeia type II apparatus (paddle method) in 900ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C for 45 minutes. In situ and externally sink method revealed the release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improved dissolution profile was observed in all the solid lipid nano particle dispersions as compared to pure drug as well as market preparation. Thus, glyceryl monostearate and ?-cyclodextrin can be successfully used as carrier for improvement of dissolution and bioavailability of glimepiride.

Rafshanjani et al., International Current Pharmaceutical Journal, September 2015, 4(10): 436-441

Downloads

Download data is not yet available.
Abstract
128
PDF
144

Downloads

Published

2015-09-08

How to Cite

Rafshanjani, M. A. S., Rahman, M. M., Parvin, S., & Kader, M. A. (2015). Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier. International Current Pharmaceutical Journal, 4(10), 436–441. https://doi.org/10.3329/icpj.v4i10.24912

Issue

Vol. 4 No. 10 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).