Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus

Authors

  • Vishal Kumar Department of Pharmacy Vivek College of Technical Education Bijnor-246726 (U.P.)
  • Saurabh Sharma Department of Pharmacy Vivek College of Technical Education Bijnor-246726 (U.P.)
  • Asif Husain Department of Pharmaceutical Chemistry Faculty of Pharmacy Jamia Humdard New Delhi-110062

DOI:

https://doi.org/10.3329/icpj.v4i12.25597

Keywords:

1, 3, 4-oxadiazole derivatives, synthesis, aryl acids, anti-inflammatory activity, analgesic activity, spectroscopy

Abstract

The aim of the present work is to synthesize and evaluate the anti-inflammatory and analgesic activity of 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3-benzathiazole derivatives. In the present investigation, a series of 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3-benzathiazole derivatives (3a1-3a9) were synthesized by condensing benzothiazolyl carboxyhydrazide and appropriate aryl acids in the presence of phosphorous oxychloride. Structures of synthesized compounds were established on the basis of IR, 1H NMR, and Mass spectroscopy. All the synthesized compounds were screened for their in-vivo anti-inflammatory and analgesic activities at the dose of 50 mg/kg and 10 mg/kg po. The biological result shows that some compounds were good in their anti-inflammatory and analgesic actions.

Kumar et al., International Current Pharmaceutical Journal, November 2015, 4(12): 457-461

Downloads

Download data is not yet available.
Abstract
161
PDF
123

Author Biography

Vishal Kumar, Department of Pharmacy Vivek College of Technical Education Bijnor-246726 (U.P.)

Uttarakhand Technical University, Post Office Chandanwadi, Prem Nagar, Suddhowala, Dehradun- 248007 (U.K), India

Downloads

Published

2015-11-07

How to Cite

Kumar, V., Sharma, S., & Husain, A. (2015). Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus. International Current Pharmaceutical Journal, 4(12), 457–461. https://doi.org/10.3329/icpj.v4i12.25597

Issue

Vol. 4 No. 12 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).