Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model

Authors

  • Rubab Tarannum Islam Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202
  • Ahmed Tanjimul Islam Medical officer Department of Neurology Chittagong Medical College and Hospital Chittagong- 4203
  • Mir Monir Hossain Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202
  • Kishor Mazumder Department of Pharmacy University of Science and Technology Chittagong Chittagong- 4202

DOI:

https://doi.org/10.3329/icpj.v5i1.25869

Keywords:

Sunflower seeds, asteraceae, general behaviour, antidepressant activity, anxiolytic activity

Abstract

Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The results revealed that the methanol extract of Helianthus annuus seeds at 100 and 200 mg/kg caused a significant increase in the spontaneous activity (general behavioural profile), moderate increase in anxiolytic activity (light-dark box and elevated plus maze test) and remarkable increase in antidepressant activity (tail suspension test). The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.

Islam et al., International Current Pharmaceutical Journal, December 2015, 5(1): 1-4

Downloads

Download data is not yet available.
Abstract
114
PDF
150

Downloads

Published

2015-12-07

How to Cite

Islam, R. T., Islam, A. T., Hossain, M. M., & Mazumder, K. (2015). Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model. International Current Pharmaceutical Journal, 5(1), 1–4. https://doi.org/10.3329/icpj.v5i1.25869

Issue

Vol. 5 No. 1 (2015)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).