In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds

Authors

  • Rubab Tarannum Islam Department of Pharmacy University of Science and Technology Chittagong (USTC) Chittagong- 4202
  • Ahmed Tanjimul Islam Department of Neurology Chittagong Medical College and Hospital Chittagong- 4203
  • Mir Monir Hossain Department of Pharmacy University of Science and Technology Chittagong (USTC) Chittagong- 4202
  • Kishor Mazumder Department of Pharmacy University of Science and Technology Chittagong (USTC) Chittagong- 4202

DOI:

https://doi.org/10.3329/icpj.v5i4.27019

Keywords:

Helianthus annuus, asteraceae, analgesic, writhing method, hot plate test

Abstract

The sunflower seed is the seed of the sunflower (Helianthus annuus). The methanol extract of seeds of Helianthus annuus were screened for analgesic activity in mice model to systematically explore the medicinal values of the plant. Acetic acid induced writhing and hot plate methods were used to confirm the central and peripheral analgesic action. In case of acetic acid-induced writhing test the extract showed significant (P <0.05) analgesic potential at doses 100 and 200 mg/kg body weight (50.35 and 57.85% inhibition, respectively). In the hot plate method, increase (p < 0.05) of latency period was also observed in comparison to standard aspirin. At 60 minutes, the latency period of two different doses (100 and 200 mg/kg body weight) was found at 13 ± 0.91 and 16.5 ± 1.55 second. The results obtained support the use of Helianthus annuus seeds in painful conditions acting both centrally and peripherally.

Islam et al., International Current Pharmaceutical Journal, March 2016, 5(4): 38-40

http://www.icpjonline.com/documents/Vol5Issue4/02.pdf

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Published

2016-03-15

How to Cite

Islam, R. T., Islam, A. T., Hossain, M. M., & Mazumder, K. (2016). In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds. International Current Pharmaceutical Journal, 5(4), 38–40. https://doi.org/10.3329/icpj.v5i4.27019

Issue

Vol. 5 No. 4 (2016)

Section

Original Articles

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