Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite

Authors

  • Reza Hoseinpour Kouhestany Faculty of Chemistry University of Mazandaran P.O. Box 47416?95447, Babolsar
  • Seyed Naser Azizi Faculty of Chemistry University of Mazandaran P.O. Box 47416?95447, Babolsar
  • Parmis Shakeri Faculty of Chemistry University of Mazandaran P.O. Box 47416?95447, Babolsar
  • Shaghyegh Rahmani Faculty of Chemistry University of Mazandaran P.O. Box 47416?95447, Babolsar

DOI:

https://doi.org/10.3329/icpj.v5i7.28037

Keywords:

CdS quantum dot, Sensitized chemiluminescence, Ce(IV)–sulfite, Cetirizine

Abstract

A new chemiluminescence (CL) method using cadmium sulfide quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of cetirizine pharmaceutical formulation. CdS QDs were synthesized by using water soluble route. The nanoparticles were structurally and optically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Ultra Violet-Visible (UVVis) absorption spectroscopy and scanning electron microscopy (SEM). In this study results shows that CdS quantum dots are enhancers of the weak CL emission. Trace amounts of cetirizine improved the sensitize effect of CdS quantum dots yielding a significant chemiluminescence enhancement of the Ce(IV)SO32?CdS QDs system. So, a new CL analysis system was selected for the determination of cetirizine. There is a good linear relationship between the relative chemiluminescence intensity and the concentration of cetirizine in the range of 1×10?9 1×10?6 molL?1 with a correlation coefficient (R2) of 0.9963 at the optimum conditions. The limit of detection (LOD) of this system was found to be 5×10?11 M. This method is simple, sensitive and cost effective, and also is accommodating for pharmaceutical applications.

Kouhestany et al., International Current Pharmaceutical Journal, June 2016, 5(7): 59-62

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Published

2016-06-05

How to Cite

Kouhestany, R. H., Azizi, S. N., Shakeri, P., & Rahmani, S. (2016). Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite. International Current Pharmaceutical Journal, 5(7), 59–62. https://doi.org/10.3329/icpj.v5i7.28037

Issue

Vol. 5 No. 7 (2016)

Section

Original Articles

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