Antioxidant and cytotoxic potential of methanol extract of <i>Tabernaemontana divaricata</i> leaves

Authors

  • Nowshin Nowaz Rumzhum Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka
  • Md Mostafizur Rahman Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka
  • Md Khalequzzaman Kazal Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka

DOI:

https://doi.org/10.3329/icpj.v1i2.9446

Keywords:

Tabernaemontana divaricata, Apocynaceae, Antioxidant, Cytotoxicity

Abstract

The methanolic extract obtained from the leaves of Tabernaemontana divericata (Family: Apocynaceae) was evaluated for in vitro antioxidant potential by determination of total antioxidant capacity, assay of nitric oxide scavenging activity and reducing power test. The extract was also screened for its cytotoxic effect using brine shrimp lethality bioassay. The results revealed potent antioxidant property in all antioxidant assays compared to the reference antioxidant, ascorbic acid in a dose dependent manner. Further, the methanolic extract of Tabernaemontana divericata showed significant cytotoxic effect (LC50: 3.12μg/ml) compared with positive control, Vincristine Sulphate (LC50: 0.331μg/ml).

Key Words: Tabernaemontana divaricata; Apocynaceae; Antioxidant; Cytotoxicity.

DOI: http://dx.doi.org/10.3329/icpj.v1i2.9446

International Current Pharmaceutical Journal 2012, 1(2): 27-31

Downloads

Download data is not yet available.
Abstract
135
PDF
102

Downloads

How to Cite

Rumzhum, N. N., Rahman, M. M., & Kazal, M. K. (2012). Antioxidant and cytotoxic potential of methanol extract of <i>Tabernaemontana divaricata</i> leaves. International Current Pharmaceutical Journal, 1(2), 27–31. https://doi.org/10.3329/icpj.v1i2.9446

Issue

Vol. 1 No. 2 (2012)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

  1. The journal holds copyright and publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).