Validated Spectrophotometric Method for Estimation of Olmesartan Medoxomil in Pharmaceutical Formulation

Authors

  • Abdullah Al Masud Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Mahfuzur Rahman Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Moynul Hasan Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Kamal Hossain Ripon Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Ahsanur Rahman Khan Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Rabiul Islam Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Raihan Sarkar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/ijpls.v1i3.12980

Keywords:

Olmesartan Medoxomil, Spectroscopy, Estimation, Validation

Abstract

A simple, sensitive and accurate spectrophotometric method has been developed for the deterrmination of Olmesartan Medoxomil in raw material and tablets. The ?max of Olmesartan Medoxomil was found to be 256 nm. The linear dynamic response was found to be in the concentration range of 4-14 ?g/mL and coefficient of correlation was found to be 0.9993. The %RSD value was below 2.0 for intraday and interday precision indicated that the method was highly precise. The LOD and LOQ were found to be 0.105 and 0.3045 ?g/mL respectively which revealed that method was highly sensitive. The percentage recovery value was higher than 100 %, indicating the accuracy of the method and absence of interference of the excipients present in the formulation. The proposed method was simple, fast, accurate, precise and reproducible and hence can be applied for routine quality control analysis of Olmesartan Medoxomil in bulk and pharmaceutical formulations.

DOI: http://dx.doi.org/10.3329/ijpls.v1i3.12980

International Journal of Pharmaceutical and Life Sciences Vol.1(3) 2012

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Published

2012-12-15

How to Cite

Al Masud, A., Rahman, M. M., Hasan, M., Ripon, M. K. H., Khan, A. R., Islam, M. R., & Sarkar, M. R. (2012). Validated Spectrophotometric Method for Estimation of Olmesartan Medoxomil in Pharmaceutical Formulation. International Journal of Pharmaceutical and Life Sciences, 1(3). https://doi.org/10.3329/ijpls.v1i3.12980

Issue

Vol. 1 No. 3 (2012)

Section

Research Articles