Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution

Authors

  • Mikhail Vladimirovich Arisov Ectoparasitoses laboratory, 28 Bolshaya, Cheremushkinskaya Street, Moscow 117218, Russia
  • Evgenia Nikolaevna Indyuhova Ectoparasitoses laboratory, 28 Bolshaya, Cheremushkinskaya Street, Moscow 117218, Russia
  • Gulnara Bakitovna Arisova Ectoparasitoses laboratory, 28 Bolshaya, Cheremushkinskaya Street, Moscow 117218, Russia

Keywords:

Fipronil; moxidectin; pharmacokinetics; praziquantel; pyriproxyfen

Abstract

Objective: The object of the study was to examine the major pharmacokinetic parameters after a single application of a complex drug preparation for veterinary use based on fipronil, praziquan­tel, moxidectin, and pyriproxyfen in cats and dogs.

Materials and Methods: For dogs, the drug preparation was administered spot-on solution in the following dosage of active pharmaceutical substances: fipronil 27.0 mg/kg body weight (bwt), praziquantel 10.8 mg/kg bwt, moxidectin 6.75 mg/kg bwt, and pyriproxyfen 5.4 mg/kg bwt; for cats, the dosage was the following: fipronil 43.2 mg/kg bwt, praziquantel 17.28 mg/kg bwt, mox­idectin 4.32 mg/kg bwt, and pyriproxyfen 8.64 mg/kg bwt. The blood samples were taken from dogs and cats. The principle of the method for determining praziquantel, trans-4-hydroxyprazi­quantel, pyriproxyfen, and fipronil in serum samples was chromatographed in a high-pressure liquid chromatograph with detection by means of a mass-spectrometric detector. The moxidectin content of the blood was detected by high-performance liquid chromatography.

Results: The drug preparation active substances: praziquantel, fipronil, and moxidectin are absorbed into the blood of dogs and cats. The penetration of praziquantel into the systemic cir­culation and further into organs and tissues was proved. After topical administration, moxidectin is absorbed and distributed systemically and is slowly removed from the plasma, which manifests itself in detectable concentrations of moxidectin in the blood for 1 month.

Conclusion: The present results of pharmacokinetic investigations may promote to the determi­nation of effective therapy strategy and prophylaxis of parasitic diseases in dogs and cats.

J. Adv. Vet. Anim. Res., 6(1): 25-32, March 2019

Downloads

Download data is not yet available.
Abstract
17
PDF
24

Downloads

Published

2019-03-31

How to Cite

Arisov, M. V., Indyuhova, E. N., & Arisova, G. B. (2019). Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution. Journal of Advanced Veterinary and Animal Research, 6(1), 25–32. Retrieved from https://banglajol.info/index.php/JAVAR/article/view/40829

Issue

Vol. 6 No. 1 (2019)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).