Synthesis and characterization of new iminopyridazine butyronitrile hydrobromides

Authors

  • Mohammad Mostafizur Rahman Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Md Din Islam Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Zakia Islam Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Samiron Kumar Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Tahmina Akter Chowdhury Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Hiroshi Nishino Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan
  • Md Aminul Haque Department of Chemistry, Jagannath University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbas.v44i2.51457

Keywords:

Pyridazines, Iminopyri-dazines, Competitive antagonists, GABA, GABA receptor antagonists

Abstract

In this study, general methods were applied for the preparation of new iminopyridazine butyronitriles. A series of six new 4-(3-aryl-1,6-dihydro-6-iminopyridazin-1-yl)butyronitrile hydro-bromides (2a-2f) (Scheme 1) have been prepared starting from commercially available 3-amino-6-chloropyridazine in two steps with good yields. The synthesized compound’s structures were characterized by IR, 1H NMR and high-resolution mass structures spectral (HRMS) data.

Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, 131-138, 2020

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Published

2021-01-19

How to Cite

Rahman, M. M., Islam, M. D., Islam, Z., Kumar, S., Chowdhury, T. A., Nishino, H., & Haque, M. A. (2021). Synthesis and characterization of new iminopyridazine butyronitrile hydrobromides. Journal of Bangladesh Academy of Sciences, 44(2), 131–138. https://doi.org/10.3329/jbas.v44i2.51457

Issue

Vol. 44 No. 2 (2020)

Section

Research Articles