Synthesis, characterization and pharmacokinetic studies of 4-(3-aryl-1, 6-dihydro-6-iminopyridazin-1-yl)butanoic acid hydrochlorides

Authors

  • Md Din Islam Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Samiron Kumar Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Tahmina Akter Chowdhury Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Mahe Zame Sarker Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Hiroshi Nishino Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan
  • Md Aminul Haque Department of Chemistry, Jagannath University, Dhaka, Bangladesh
  • Mohammad Mostafizur Rahman Department of Chemistry, Jagannath University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jbas.v45i1.54258

Keywords:

Iminopyridazines, GABA, GABA receptor, Pharmacokinetic, Competitive antagonists

Abstract

A series of six title compounds have been prepared using 3-amino- 6-chloropyridazine as starting material collected from commercial sources and were characterized by IR, 1H NMR, and high-resolution mass spectral (HRMS) data. The method involves three steps: Suzuki-Miyaura cross-coupling reaction, N(2)-alkylation, and acid hydrolysis, respectively, to obtain final products with good yields. According to Lipinski's rule of five and Veber's rule, pharmacokinetics studies of the synthesized compounds showed that all the parameters were in between the permissible limits. The toxicity parameters were low for the compounds to act as drugs.

J. Bangladesh Acad. Sci. 45(1); 37-47: June 2021

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Published

2021-07-15

How to Cite

Islam, M. D., Kumar, S., Chowdhury, T. A., Sarker, M. Z., Nishino, H., Haque, M. A., & Rahman, M. M. (2021). Synthesis, characterization and pharmacokinetic studies of 4-(3-aryl-1, 6-dihydro-6-iminopyridazin-1-yl)butanoic acid hydrochlorides. Journal of Bangladesh Academy of Sciences, 45(1), 37–47. https://doi.org/10.3329/jbas.v45i1.54258

Issue

Section

Research Articles