A qualitative structure activity relationship (SAR) study of selected pyroglutamates

Authors

  • Halima Bagum The Department of Chemistry, University of Barishal, Barishal, Bangladesh.
  • Mark G Moloney The Department of Chemistry, University of Oxford, Oxford, United Kingdom.
  • Md Rabiul Islam The Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/jbas.v48i2.70546

Keywords:

antibacterial screening, pyroglutamate, pyrrolinone, pyrrolidinone

Abstract

A library of Pyroglutamate derivatives (Fig. 1-4: 8a-8f, 9a-9d, 10a-10e, 11a-11f, 12a-12c, 13 and 14) have been analysed qualitatively to investigate their Structure Activity Relationships (SAR). Antibacterial screening data used for this work was against the selected multidrug-resistant pathogens including both Gram-negative and Gram-positive bacteria. Among the synthesized compounds, pyroglutamates 8e and 11d are more potent as antibacterial agent.

J. Bangladesh Acad. Sci. 48(2); 165-170: December 2024

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Published

2024-12-31

How to Cite

Bagum, H., G Moloney, M., & Islam, M. R. (2024). A qualitative structure activity relationship (SAR) study of selected pyroglutamates. Journal of Bangladesh Academy of Sciences, 48(2), 165–170. https://doi.org/10.3329/jbas.v48i2.70546

Issue

Vol. 48 No. 2 (2024)

Section

Research Articles

License

Copyright (c) 2024 Journal of Bangladesh Academy of Sciences

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