PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c

Abstract

Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung function.

Objectives: To observe PEFR, FEF_25-75 and MVV and their relationship with HbA_1c in type- 1 diabetic male in Bangladesh.

Methods: This cross-sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January and 31st December 2009. A total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as control. For assessment of lung function PEFR, FEF_25-75 and MVV of all the subjects were measured by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated hemoglobin (HbA_1c) levels of diabetic patients were also measured by usual laboratory technique. Data were analyzed by unpairedt test and Pearsons correlation coefficient test.

Results: PEFR (p<0.001), FEF_25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF_25-75 (p>0.05), and MVV (p<0.05) were negatively correlated with HbA_1c.

Conclusion: The lung functions were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction is mainly due to poor glycemic control.

DOI: http://dx.doi.org/10.3329/jbsp.v8i1.16642

J Bangladesh Soc Physiol. 2013, June; 8(1): 16-20