Leptin and Other Factors as Determinants of Insulin Secretion and Sensitivity in Bangladeshi Type 2 Diabetic Subjects

Authors

  • Manindra Nath Roy Associate Professor of Biochemistry, Begum Khaleda Zia Medical College, Dhaka-1207
  • Salima Akter Department of Biochemistry & Cell Biology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka-1000
  • Mohammad Jafarulla Associate Professor of Biochemistry, Medical College for Women and Hospital, Uttara, Dhaka-1230
  • Forhadul Hoque Mollah Associate Professor of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka-1000
  • Ajanta Rani Saha Medical Officer, Pediatrics OPD, Shaheed Surawardy Hospital, Dhaka- 1207
  • Liaquat Ali Professor of Biochemistry and Cell Biology, BIRDEM, Dhaka-1000.

DOI:

https://doi.org/10.3329/jbsp.v3i0.1786

Keywords:

Leptin, Insulin, Diabetes

Abstract

Background: The relative contribution of insulin secretion and sensitivity in the development of Type 2 diabetes mellitus (T2DM) vary from population to population due to the heterogeneous nature of the disease. The study was undertaken to evaluate insulin secretory capacity and sensitivity in a Bangladeshi Type 2 diabetic population and to explore the association of some of the anthropometric and biochemical factors known to modulate B-cell function and insulin action.

Methods: Ninety one T2DM subjects and 32 age-matched controls were studied for their fasting plasma glucose (FPG), lipids, HbA1c (by HPLC), leptin and C-peptide (ELISA). Insulin secretion (HOMA B) and insulin sensitivity (HOMA S) were calculated by homeostasis model assessment (HOMA).

Results: Both insulin secretion and sensitivity were significantly reduced in diabetic as compared to control (HOMA B%, geometric mean±SD, 35.65±1.75 vs. 96.29±1.50, p < 0.001; HOMA S%, 68.66±1.71 vs. 104.951.63, p < 0.001). However, B-cell dysfunction was predominant than insulin resistance in predicting T2DM as the discriminate function coefficient for HOMA B (1.098) was greater than that for HOMA S (0.821). In T2DM, HOMA B had positive correlation with BMI (r=0.368, p < 0.001) and HOMA S was inversely correlated to BMI (r=-0.261, p < 0.01), WHR (r=-0.258, p < 0.01) and plasma TG (r=-0.233, p < 0.001). On multiple regression analysis HOMA B and HOMA S were found to be inversely associated to FPG (p < 0.001) and leptin (p < 0.05) in T2DM.

Conclusions: Both insulin secretory dysfunction and insulin resistance are present in Bangladeshi T2DM subjects, but B-cell failure seems to be the predominant abnormality. BMI, plasma glucose, insulin and leptin are the major determinants of insulin secretory capacity and generalized as well as central obesity, plasma glucose, triglycerides, insulin and leptin are among the major determinants of insulin sensitivity in this population.

Key Words: Leptin, Insulin, Diabetes  

doi: 10.3329/jbsp.v3i0.1786

J Bangladesh Soc Physiol. 2008 Dec;(3):1-7.

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How to Cite

Roy, M. N., Akter, S., Jafarulla, M., Mollah, F. H., Saha, A. R., & Ali, L. (2009). Leptin and Other Factors as Determinants of Insulin Secretion and Sensitivity in Bangladeshi Type 2 Diabetic Subjects. Journal of Bangladesh Society of Physiologist, 3, 1–7. https://doi.org/10.3329/jbsp.v3i0.1786

Issue

Vol. 3 (2008)

Section

Articles

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