Erratum: Effect of Nigella sativa (Kalozira) oil on pain in Long Evans rats. J Bangladesh Soc Physiol 2018, June;13(1):1-7

Abstract

The author of this article brought attention to publishers that there were errors on page 1,3,4,5 published in previous issue. These errors have been corrected to enhance credibility to readers and the whole corrected article has been published in this issue of JBSP.

The online version of the original article can be found at doi:http:/ /dx.doi.org/10.3329/jbsp,v13i1.37840(http://banglajol.info/ index.php/JBSP/article/view/37840)

Background: For thousands of years, Nigella sativa has been used in many countries as a spice as well as a protective and curative remedy for numerous health disorders. Nigella sativa oil (NSO) suppressed pain in animal models.

Objective: To assess the effects of Nigella sativa oil on pain after single administration with three increasing doses in rat models.

Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2016 to February 2017. For this, 20 (twenty) Long Evans rats (200±20) of both sexes were divided into control ( 10 ml/kg of 1% solution of Tween 20) and experimental groups (NSO 0.5, with 0.5 ml/kg NSO; NSO 1, with 1 ml/kg NSO; NSO 1.5, with 1.5 ml/kg NSO) with 5 rats in each group. To assess nociceptive pain, central analgesic system and inflammatory pain early phase (1^st-5^th minutes); inter phase (6th-15th minutes) and late phase (16th-60th minutes) of formalin test respectively were observed. All the agents were given intraperitoneally in a single dose just one hour before the formalin test. In all phases, total frequency of jerking and total duration of flexing and licking of right hind paw were counted after administration of subcutaneous formalin (50 mL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni’s post hoc test.

Results: In early phase, NSO significantly reduced the jerking (p ≤0.001, in all doses) and flexing and licking (p ≤0.001, in higher 2 doses). In interphase, jerking was significantly (p ≤0.01) lowered after 1.5 ml/kg of NSO but flexing and licking significantly lowered by all 3 doses (p ≤0.05, p ≤ 0.001, p≤ 0.001). In addition, in late phase jerking and flexing and licking was reduced by higher 2 doses (p ≤0.001) and all 3 doses respectively (p ≤ 0.001, in all doses).

Conclusion: From this study, it may be concluded that, NSO possess analgesic effect and higher two doses were more effective than lower doses.

J Bangladesh Soc Physiol. 2018, December; 13(2): 84-90