Effects of Jatropha curcas seed extract on reproductive functions in female Wistar rats

Authors

  • Taofeek Olanrewaju Ayinde Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
  • Azeez Olaniyi Adetokunbo Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
  • Sikiru Abayomi Biliaminu Department of Chemical Pathology, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria
  • Sheriff Lekan Ojulari Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
  • MI AbdulAzeez Department of Chemical Pathology, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria
  • Adeleke Alani Faramade Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria
  • Maruf Eyitayo Balogun Department of Physiology, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
  • Adam Moyosore Afodun Department of Anatomy and Cell Biology, Faculty of Health Sciences, Busitema University, Uganda
  • Muideen Tella Liadi Department of Crop Production, Faculty of Agriculture, University of Ilorin, Ilorin, Nigeria
  • Moshood Adewale Belewu Department of Animal Production, Faculty of Agriculture, University of Ilorin, Ilorin, Nigeria

DOI:

https://doi.org/10.3329/jbsp.v16i2.57571

Keywords:

Contraceptive, Hypothalamus, Hormones, Jatropha, Ovary, Pituitary

Abstract

Background: Jatropha curcas is a multipurpose plant with several industrial and medicinal importance. Its seeds contain many active compounds that are used as medicines with antiinflammatory, and antioxidant activity.

Objective: The objective of this study is to evaluate the effects of extract of Jatropha curcas seed which is patronized locally in some communities as agent of preventing childbirth on reproductive functions in female Wistar rats.

Methods: Twenty-four animals were randomly divided into four groups of 6 rats each. Group I was administered normal saline and served as control. Groups II, III and IV were given the seed extract orally at doses of 100mg/kg, 200mg/kg and 400mg/kg body weight respectively daily for 14days orally. The animals were euthanised and blood samples collected for oestrogen, progesterone, FSH and LH assay. Statistical analysis was done using statistical package for social sciences (SPSS). Differences in means was obtained using ANOVA test. All values reported in the study were expressed as mean ± SEM. Differences in mean was taken to be significant at P<0.05.

Results: There was significant reduction (p<0.05) in levels of progesterone, LH and FSH in moderate and high doses of the extract. But estrogen level was significantly (p<0.05) decreased in both low and moderate doses, while the high dose showed significant (p<0.05) increase.

Conclusion: There was alteration in reproductive hormones due to arrest of development of ovarian follicles. This gives it the propensity of exhibiting contraceptive activity.

J Bngladesh Soc Physiol 2021;16(1): 104-110

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Published

2022-02-13

How to Cite

Ayinde, T. O., Adetokunbo, A. O. ., Biliaminu, S. A. ., Ojulari, S. L. ., AbdulAzeez, M., Faramade, A. A. ., Balogun, M. E. ., Afodun, A. M. ., Liadi, M. T. ., & Belewu, M. A. . (2022). Effects of Jatropha curcas seed extract on reproductive functions in female Wistar rats. Journal of Bangladesh Society of Physiologist, 16(2), 104–110. https://doi.org/10.3329/jbsp.v16i2.57571

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