FVC, FEV<sub>1</sub> and FEV<sub>1</sub> / FVC % in Hypothyroid Female and their Relationships with Thyroid Hormones

Authors

  • Pervin Akter Assistant Professor, Department of Physiology , Delta Medical College and Hospital, Dhaka
  • Shelina Begum Chairman, Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU)
  • Taskina Ali Assistant Professor, Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU)
  • Noorzahan Begum Former chairman, Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU)

DOI:

https://doi.org/10.3329/jbsp.v6i1.8084

Keywords:

FVC, FEV1, FEV1/FVC%, Hypothyroidism

Abstract

Background: Hypothyroidism is a common hormonal disorder affecting various organs including lungs. It may be associated with respiratory symptoms and can decrease lung function.

Objective: To observe FVC, FEV1 and FEV1/ FVC % in hypothyroid female patients.

Methods: This crosssectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from 1st July 2008 to 30th June 2009 on 60 hypothyroid female patients of 30-50 years age (Group B). For comparison, 30 age and BMI matched apparently healthy subjects (Group A) were also studied. Based on receiving treatment, hypothyroid patients were divided into B1 (untreated patients on their 1st day of diagnosis) and B2 (patients treated for at least 12-18 months). They were selected from the Out Patient Department of Endocrinology wing of department of Medicine, BSMMU, Dhaka. Serum TSH and FT4 levels were measured by Microparticle Enzyme Immunoassay (MEIA) principle in AxSYM system. The FVC, FEV1, FEV1/FVC%, of all the subjects were measured by a digital MicroDL spirometer. Data were analyzed by One way ANOVA test, Independent sample t- test and Pearson’s correlation coefficient test.

Results: The mean percentage of predicted values of all the lung function variables in healthy female subjects and treated hypothyroids were within normal ranges. However, all of them were lower in untreated hypothyroids in comparison to those of control and treated hypothyroids.FVC and FEV1 showed statistically significant (p<0.001) difference and FEV1/FVC% showed non significant difference . In addition, all the ventilatory variables had negative correlation with serum TSH level and positive correlation with serum FT4 level and these relationships were statistically significant in control (p<0.001) and treated hypothyroids (p<0.01).

Conclusion: This study reveals that lung function may be lower in untreated hypothyrod patients and correlated with thyroid hormones. Treatment of hypothyroids may reverse this changes.

Key words: FVC, FEV1 , FEV1/FVC%, Hypothyroidism   

DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8084

J Bangladesh Soc Physiol. 2011 June; 6(1): 45-51

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How to Cite

Akter, P., Begum, S., Ali, T., & Begum, N. (2011). FVC, FEV<sub>1</sub> and FEV<sub>1</sub> / FVC % in Hypothyroid Female and their Relationships with Thyroid Hormones. Journal of Bangladesh Society of Physiologist, 6(1), 45–51. https://doi.org/10.3329/jbsp.v6i1.8084

Issue

Vol. 6 No. 1 (2011)

Section

Articles

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