Effect of vitamin C on brain electrical activity in female patients with Metabolic Syndrome
DOI:
https://doi.org/10.3329/jbsp.v20i2.87052Keywords:
Metabolic Syndrome, EEG, brain waves, vitamin C, absolute powerAbstract
Background: Metabolic syndrome (MetS) is a global endocrine disorder associated with higher low-frequency and lower high-frequency brain wave electrical activity. Vitamin C supplementation can alter brain wave patterns. Objective: To evaluate the effect of vitamin C on brain wave activity of female patients with MetS using power spectral analysis of Electroencephalogram(EEG). Methods: In this experimental investigation, 20 female patients with MetS, ages 25 to 35, were enrolled. Age-matched control group of twenty healthy female volunteers was also included. Using the EEG Traveler BrainTech 32+ CMEEG-01 system (India), EEG recordings were done for five minutes while the subject was at rest and with their eyes closed. The BT40 analytic software was used to analyze the absolute power of different frequency bands of EEG. The MetS patients received 500 mg of vitamin C orally twice daily for 8 weeks. The Independent Samples T test and the Paired Samples T test were used for statistical comparisons. Results: Compared to controls, MetS patients exhibited significantly higher absolute power in delta, theta waves, and lower alpha, beta waves across all electrodes and cortical regions at baseline. After 8 weeks of vitamin C supplementation, delta and theta power significantly decreased, while alpha and beta wave power increased in most cortical areas. Conclusion: MetS was associated with higher low frequency waves, and lower high frequency waves. Vitamin C supplementation was effective to reverse the altered brain waves in MetS patients.
J Bangladesh Soc Physiol 2025;20(2): 58-71
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1. International Diabetes Federation. The IDF consensus worldwide definition of the Metabolic Syndrome. 2006; [Internet]. [cited on 27 May, 2024]. Available from: https://idf.org/media/uploads/2023/05/attachments-30.pdf.
2. Noubiap JJ, Nansseu JR, Lontchi-Yimagou E, Nkeck JR, Nyaga UF, Ngouo AT, Tounouga DN, Tianyi FL, Foka AJ, Ndoadoumgue AL, Bigna JJ. Geographic distribution of metabolic syndrome and its components in the general adult population: a meta-analysis of global data from 28 million individuals. Diabetes Res Clin Pract. 2022; 88: 109924. DOI: 10.1016/j.diabres.2022.109924.
3. Chowdhury MZI, Anik AM, Farhana Z, Bristi PD, Abu Al Mamun BM, Uddin MJ, Fatema J, Akter T, Tani TA, Rahman M, Turin TC. Prevalence of metabolic syndrome in Bangladesh: A systematic review and meta-analysis of the studies. BMC Public Health. 2018; 18 (1): 308. DOI: 10.1186/s12889-018-5209-z.
4. Rajak BL, Gupta M, Bhatia D, Mukherjee A, Paul S, Sinha TK. Power spectrum density analysis of EEG signals in spastic cerebral palsy patients by inducing r-TMS therapy. J Biomed Eng. 2016; 4 (1): 7-11.
5. Olbrich S, Arns M. EEG biomarkers in major depressive disorder: Discriminative power and prediction of treatment response. Int Rev Psychiatry. 2013; 25 (5): 604-18. DOI: 10.3109/09540261.2013.816269.
6. Blume M, Schmidt R, Hilbert A. Abnormalities in the EEG power spectrum in bulimia nervosa, binge-eating disorder, and obesity: a systematic review. Eur Eat Disord Rev. 2019; 27 (2): 124-36. DOI: 10.1002/erv.2654.
7. Baskaran A, Milev R, McIntyre RS. A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder. Neuropsychiatr Dis Treat. 2013; 9: 143-50. DOI: 10.2147/NDT.S38720.
8. Ellulu MS, Rahmat A, Patimah I, Khaza'ai H, Abed Y. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Des Devel Ther. 2015; 9: 3405-12. DOI: 10.2147/DDDT.S83144.
9. Mukadam FM, Gawali UP, Pore SM. Effect of vitamin C on blood glucose levels, glycosylated hemoglobin, and serum lipid profile in patients with type 2 diabetes mellitus: A prospective study. J Diabetol. 2024; 15 (3): 273-78. DOI: 10.4103/jod.jod_32_24.
10. Rahman F, Al Frouh F, Bordignon B, Fraterno M, Landrier JF, Peiretti F, Fontes M. Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool. Front Cell Dev Biol. 2014; 2: 29. DOI: 10.3389/fcell.2014.00029.
11. Kaya F, Belin S, Bourgeois P, Micaleff J, Blin O, Fontés M. Ascorbic acid inhibits PMP22 expression by reducing cAMP levels. Neuromuscul Disord. 2007; 17 (3): 248-53. DOI: 10.1016/j.nmd.2006.12.008.
12. Totan B, Baygut H, Karadag MG. Vitamin C physiology: the known and the unknown in obesity. J Food Nutr Res. 2019; 7 (8): 613-18. DOI:10.12691/jfnr-7-8-9.
13. Montero D, Walther G, Stehouwer CD, Houben AJ, Beckman JA, Vinet A. Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2014; 15 (2): 107-16. DOI: 10.1111/obr.12114.
14. Siavash M, Amini M. Vitamin C may have similar beneficial effects to Gemfibrozil on serum high-density lipoprotein-cholesterol in type 2 diabetic patients. J Res Pharm Pract. 2014; 3 (3): 77-82. DOI: 10.4103/2279-042X.141075.
15. Gaur GS, Dixit AK. Comparative study of vitamin C on serum lipid profile in healthy male and female human subjects. J Sci Res. 2012; 4 (3): 775-81. DOI: 10.3329/jsr.v4i3.8894.
16. Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, Salvetti A. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007; 20 (4): 392-97. DOI: 10.1016/j.amjhyper.2006.09.021.
17. Jariyapongskul A, Rungjaroen T, Kasetsuwan N, Patumraj S, Seki J, Niimi H. Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats. Microvasc Res. 2007; 74 (1): 32-38. DOI: 10.1016/j.mvr.2007.03.002.
18. Kazmierska P, Grebowski J, Konopacki J. Does an anti‐oxidant ascorbic acid improve the condition of hippocampal formation slice preparations? -a micro‐EEG approach. Int J Exp Pathol. 2012; 93 (6): 406-13. DOI: 10.1111/j.1365-2613.2012.00838.x
19. Sayorwan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi, N. The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activity. J Med Assoc Thai. 2012; 95 (4): 598-606.
20. Choi N, Wu Y, Park S. Effects of olfactory stimulation with aroma oils on psychophysiological responses of female adults. IJERPH. 2022; 19 (9): 5196.
DOI: 10.3390/ ijerph19095196.
21. Gulluni N, Re T, Loiacono I, Lanzo G, Gori L, Macchi C, Epifani F, Bragazzi N, Firenzuoli F. Cannabis essential oil: a preliminary study for the evaluation of the brain effects. ECAM. 2018; 2018: 1-11
22. Korb AS, Cook IA, Hunter AM, Leuchter AF. Brain electrical source differences between depressed subjects and healthy controls. Brain Topogr. 2008; 21: 138-46. DOI: 10.1007/s10548-008-0070-5.
23. Adler G, Bramesfeld A, Jajcevic A. Mild cognitive impairment in old-age depression is associated with increased EEG slow-wave power. Neuropsychobiology. 1999; 40 (4): 218-22. DOI: 10.1159/000026623
24. Öksüz Ö, Günver MG, Arıkan MK. Quantitative electroencephalography findings in patients with diabetes mellitus. Clin EEG Neurosci. 2022; 53 (3): 248-55. DOI: 10.1177/1550059421997657.
25. Sowndhararajan K, Kim S. Influence of fragrances on human psychophysiological activity: With special reference to human electroencephalographic response. Sci Pharm. 2016; 84 (4): 724-51. DOI: 10.3390/scipharm84040724.
26. Chandharakool S, Koomhin P, Sinlapasorn J, Suanjan S, Phungsai J, Suttipromma N, Songsamoe S, Matan N, Sattayakhom A. Effects of tangerine essential oil on brain waves, moods, and sleep onset latency. Molecules. 2020; 25 (20): 4865. DOI: 10.3390/molecules25204865.
27. Sayowan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi N. The harmonizing effects of citronella oil on mood states and brain activities. J Health Res. 2012; 26 (2): 69-75.
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