Association of Serum Prealbumin With Nutritional Status of End-Stage Renal Disease Patients Under Maintenance Hemodialysis

Authors

  • Mohammad Syfur Rahman Assistant Professor, Department of Nephrology, Sylhet M.A.G Osmani Medical College, Sylhet. Medical Officer, Department of Feto-Maternal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Tayeba Sultana Medical Officer, Department of Radiology & Imaging, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Tahera Sultana Assistant Professor, Department of Orthopedics, Faridpur Medical College, Faridpur, Bangladesh
  • Syed Asif Ul Alam Registrar, Department of Nephrology, National Institute of Kidney Diseases & Urology, Dhaka – 1207, Bangladesh
  • Sk Md Ershad Medical Officer, Department of Nephrology, National Institute of Kidney Diseases & Urology, Dhaka – 1207, Bangladesh
  • Sorowar Hossain

DOI:

https://doi.org/10.3329/jopsom.v40i2.61791

Keywords:

Hemodialysis; Biochemical profile; Malnutrition

Abstract

Background: End-stage renal disease (ESRD) patients undergoing maintenance hemodialysis often suffer from malnutrition. The primary objective of the study was to measure the level of serum prealbumin, assess the correlation of serum prealbumin with modified subjective global assessment score and determine a cut-off value for prealbumin that can estimate the nutritional status of the study population with highest accuracy, among ESRD patients under maintenance hemodialysis.

Methods: A one year long cross-sectional study from July 2016 to June 2017 was conducted at hemodialysis unit of SSMC & MH, BSMMU, BIRDEM hospital and NIKDU, Dhaka, among 80 maintenance hemodialysis patients. Adult patients over the age of 18 years and on regular (≥2 sessions per week) hemodialysis for more than 3 months without any acute infection were enrolled. Nutritional status of the patients was evaluated using modified subjective global assessment score. Serum prealbumin level was compared with both anthropometric and biochemical parameters, as well as with modified SGA score. Using modified SGA score as gold standard, receiver operating characteristic curve was used to estimate best fitting cut-off value for serum prealbumin for nutritional assessment among ESRD patients under maintenance hemodialysis.

Results: Mean age of study population was 52.3 years and 66.3% respondents were male. Most prominent primary renal diseases were diabetic nephropathy (48.8%). According to modified SGA score, 10% of the study population had normal nutritional status and 90% had mild to moderate malnutrition. Mean serum prealbumin was 27.8 mg/dl. Serum prealbumin showed significant negative correlation with age, modified SGA score and triglyceride; significant positive correlation was shown with BMI, serum creatinine and serum albumin. Using receiver operating characteristic curve, 32.6 mg/dl was found to be the best fitting cut-off value for nutritional assessment with 73.6% sensitivity, 62.5% specificity and 72.5% accuracy.

Conclusion: Data obtained from this study strongly indicates that serum prealbumin can be used as a marker for nutritional assessment among ESRD patients undergoing maintenance hemodialysis.

JOPSOM 2021; 40(2):9-15

Downloads

Download data is not yet available.
Abstract
31
PDF
40

Downloads

Published

2022-12-12

How to Cite

Rahman, M. S. ., Sultana, T. ., Sultana, T. ., Alam, S. A. U. ., Ershad, S. M., & Hossain, S. . (2022). Association of Serum Prealbumin With Nutritional Status of End-Stage Renal Disease Patients Under Maintenance Hemodialysis. Journal of Preventive and Social Medicine, 40(2), 9–15. https://doi.org/10.3329/jopsom.v40i2.61791

Issue

Vol. 40 No. 2 (2021)

Section

Original Articles

License

Copyright (c) 2021 Mohammad Syfur Rahman, Tayeba Sultana, Tahera Sultana, Syed Asif Ul Alam, Sk Md Ershad, Sorowar Hossain

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright Notice

Authors who publish in the Journal of Preventive and Social Medicine (JOPSOM) agree to the following terms that:

  1. Authors retain copyright and grant the Journal of Preventive and Social Medicine (JOPSOM) the right of first publication of the work.

  2. Articles in the Journal of Preventive and Social Medicine (JOPSOM) are Open Access articles published under the Creative Commons CC BY-NC License  Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). This license permits Share — copy and redistribute the material in any medium or format and Adapt — remix, transform, and build upon the material.