Isoniazid-induced Encephalopathy in a Patient with Pott’s Disease with Chronic Kidney Disease: A Case Report

Authors

  • Md Helal Miah Assistant Professor Department of Medicine Rangpur Medical College, Rangpur
  • Md Ahad Bakas MD Resident Department of Medicine Rangpur Medical College, Rangpur
  • Md Kamal Hossein Assistant Registrar Department of Medicine Rangpur Medical College, Rangpur
  • Tahmina Begum MD, Resident Department of Medicine Rangpur Medical College, Rangpur
  • Md Shafiul Alam Associate Professor Department of Medicine Rangpur Medical College, Rangpur
  • Md Jahangir Kabir Assistant Professor Department of Medicine Rangpur Medical College, Rangpur
  • Abu Said Md Rahenur Mondol Assistant Professor Department of Medicine Rangpur Medical College, Rangpur
  • Md Ruhul Amin Sarkar Assistant Professor Department of Medicine Rangpur Medical College, Rangpur
  • Md Mahfuj Ul Anwar Assistant Professor Department of Medicine Rangpur Medical College, Rangpur
  • Shah Md Sarwer Jahan Professor Department of Medicine Rangpur Medical College, Rangpur
  • Md Mahfuzer Rahman Professor and Head Department of Medicine Rangpur Medical College, Rangpur

DOI:

https://doi.org/10.3329/jrpmc.v8i1.65066

Keywords:

Chronic kidney disease, Isoniazid-induced encephalopathy, Tuberculosis

Abstract

We report an isoniazid-induced encephalopathy in a man with chronic renal failure. Drug-induced encephalopathy is a common side effect of many drugs. Isoniazid (INH), a first-line drug for tuberculosis, can cause encephalopathy in patients with chronic kidney disease (CKD). For Pott's disease of the thoracic spine, he received rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine and prednisolone. But the patient is free of pyridoxine for two and a half months. Subsequently, after treatment, the patient experienced recurrent episodes of altered consciousness, irrelevant conversations, and disorientation. After ruling out other causes, isoniazid-induced encephalopathy was suspected and confirmed by improvement of symptoms after discontinuation of high-dose isoniazid and pyridoxine.

J Rang Med Col. March 2023; Vol. 8, No. 1:72-75

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Published

2023-04-04

How to Cite

Miah, M. H. ., Bakas, M. A. ., Hossein, M. K. ., Begum, T. ., Alam, M. S. ., Kabir, M. J. ., Mondol, A. S. M. R. ., Sarkar, M. R. A. ., Anwar, M. M. U., Jahan, S. M. S. ., & Rahman, M. M. . (2023). Isoniazid-induced Encephalopathy in a Patient with Pott’s Disease with Chronic Kidney Disease: A Case Report. Journal of Rangpur Medical College, 8(1), 72–75. https://doi.org/10.3329/jrpmc.v8i1.65066

Issue

Vol. 8 No. 1 (2023)

Section

Case Report

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Copyright (c) 2023 Journal of Rangpur Medical College

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