Effect of Neem (Azadirachta Indica) on Fertility in Male Rats

Authors

  • Asma Khan Assistant Professor, Department of Pharmacology & Therapeutics, Shaheed Suhrawardy Medical College, Dhaka
  • Zinnat Ara Begum Professor & Former Head, Department Pharmacology & Therapeutics, Dhaka Medical College, Dhaka
  • Md Ismail Khan Vice- Principal & Head, Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka
  • Hasanur Rahman Assistant Professor, Department of Pharmacology & Therapeutics, Dhaka Dental College, Dhaka
  • Layla Afroza Banu Professor & Head, Department of Pharmacology & Therapeutics, Shaheed Suhrawardy Medical College, Dhaka

DOI:

https://doi.org/10.3329/jssmc.v5i1.16206

Keywords:

Azadirachta indica, antifertility effect, antispermatognic, antiandrogenic, sperm count, animal study

Abstract

Background: Azadirachta indica locally known as neem has been claimed to possess antifertility properties by many investigators.

Objective: The present study was designed to evaluate the antifertility effect of Azadirachta indica leaf powder in male rats.

Methodology: The study was carried out in pharmacology and Therapeutic Department of Dhaka Medical College during the period of January 2008 to December 2008. Total number of 24 rats was divided into 4 groups. Group A was served as control, group B, C and D were treated by Azadirachta indica leaf powder orally, inj. testosterone I/M, & Azadirachta indica leaf powder orally, inj. testosterone I/M respectively for 48 days. They were sacrificed on 49 day. Then morphological and histological study was done.

Result: The result showed that the all of the Azadirachta indica leaf powder treated rats has significant antispermatognic effect as well as antiandrogenic effect.

Conclusion: The Azadirachta indica leaf powder reduced motility and density of sperm and causes structural changes of leydig cells and seminiferous tubule.

DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16206

J Shaheed Suhrawardy Med Coll, 2013;5(1):39-42

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Published

2013-08-18

How to Cite

Khan, A., Begum, Z. A., Khan, M. I., Rahman, H., & Banu, L. A. (2013). Effect of Neem (Azadirachta Indica) on Fertility in Male Rats. Journal of Shaheed Suhrawardy Medical College, 5(1), 39–42. https://doi.org/10.3329/jssmc.v5i1.16206

Issue

Vol. 5 No. 1 (2013)

Section

Original Articles

License

Copyright ©2015 Shaheed Suhrawardy Medical College Teachers’ Association.