Role of Anti-mullerian Hormone (AMH), As A Prediction of Clinical Pregnancy Outcome in Women with Polycystic Ovarian Syndrome with Sub Fertility

Authors

  • Ashia Khatun Associate Professor, Department of Obst. & Gynae, Shaheed Suhrawardy Medical College, Dhaka
  • Afroza Kutubi Associate Professor, Department of Obst. & Gynae, Dhaka Medical College, Dhaka
  • Khairun Nahar Associate Professor, Department of Obst. & Gynae, BSMMU, Dhaka
  • Israt Jahan Assistant Professor, Department of Obst. & Gynae, Shaheed Suhrawardy Medical College, Dhaka
  • Hasina Begum Junior Consultant, Department of Obst. & Gynae, Shaheed Suhrawardy Medical College & Hospital, Dhaka
  • Tahmina Hassan Medical Officer, Department of Obst. & Gynae, Shaheed Suhrawardy Medical College & Hospital, Dhaka

DOI:

https://doi.org/10.3329/jssmc.v9i1.37250

Keywords:

Infertility, PCOS, anti-mullerian hormone, (Obs & Gynae), OPD

Abstract

Background: Anti-mullerian hormone (AMH) in largely expressed throughout folliculogenisis (by granulosa cells in ovarian follicles) but highest in pre-antral and small antral steges (<4mm) drameter of development.

Objective: To analyse the usefulness of plasma anti-mullerian hormone (AMH) measurement as a test for assessing ovarian reserve in Polycystic ovary syndrome with sub fertility,

Methodology: Women with PCOS and sub fertility, were included in this study with age group 18-35yrs. This Prospetive cohort study done in 30 cases in ShSMC with purposive randomized sampling, from January 2015 to December 2015. Serum, plasma & for evaluation of PCOS, preferably TV-USG was done.

Result: In this study we analyze 30 serum samples from patient aged between 18-35 years and transvaginal ultrasonography was done simultaneously. Mean age group of my patient was 25.2±4.7 years which correlates with AMH level in PCOS which is statistically significant (p<0.001). Mean level of AMH is 5.7±4.9 mg/ml which is also correlate with transvaginal USG scan with the feature of PCOS (p<.0.001). More than 50% woman presents with features of subfertility with PCOS and 46.7% are normal ovaries. Mean menstrual day 7.6 (4-12 days) which have a good linear correlation with irregularities of menstrual cycle and PCOS (p<0.05).

Conclusion: To conclude AMH appears to have a major inhibiting role during folliculogenesis, which may contribute to anovulation in PCOS. The reason for the raised AMH in PCOS may give clues as to the mechanism os anovulation.

J Shaheed Suhrawardy Med Coll, June 2017, Vol.9(1); 3-5

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Author Biography

Ashia Khatun, Associate Professor, Department of Obst. & Gynae, Shaheed Suhrawardy Medical College, Dhaka



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Published

2018-07-05

How to Cite

Khatun, A., Kutubi, A., Nahar, K., Jahan, I., Begum, H., & Hassan, T. (2018). Role of Anti-mullerian Hormone (AMH), As A Prediction of Clinical Pregnancy Outcome in Women with Polycystic Ovarian Syndrome with Sub Fertility. Journal of Shaheed Suhrawardy Medical College, 9(1), 3–5. https://doi.org/10.3329/jssmc.v9i1.37250

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Original Articles