Efficacy of Mannitol in the Management of Cerebral Oedema in Hypoxic Ischemic Encephalopathy Stage-II following Perinatal Asphyxia in a Tertiary Level Hospital

Abstract

Background: The use of mannitol in reducing cerebral edema in case of perinatal asphyxia in Hypoxic Ischemic Encephalopathy Stage-II is considerably contributing.

Objective: To find out the efficacy of mannitol in reducing cerebral edema in Hypoxic Ischemic Encephalopathy Stage-II following perinatal asphyxia.

Methods: It was a prospective observational study done in the Paediatric department of Shahid Suhrawardy Medical College Hospital, Dhaka from September 2016 to February 2017. According to inclusion criteria total 120 neonates were included in this study by purposive sampling.  Among them, 60 neonates were selected as case (treated with mannitol) and 60 were taken as control (treated without mannitol). Data were collected in a structured questionnaire.

Results: During the study period, a total of 120 patients were studied. In the study group (Group -A), 78.33% were delivered by LUCS whereas in Group-B, the figure was 66.6%. The mean birth weight of neonates of these two groups were 1.9 + 0.76 kg and 1.73 + 0.89 kg respectively. PROM, APH, malpresentation, and multiple gestation were statistically significant risk factors in both groups (P=<0.05). About 79.67% neonates of group-A (with mannitol) and 70% of group-B (without mannitol) had radiological improvement following treatment revealing no statistically significant difference (P= >0.05).

Conclusion: From the result of the present study, it can be concluded that there is no significant difference in the management of cerebral edema following perinatal asphyxia with HIE stage-II between the groups treated with mannitol and without mannitol.

J Shaheed Suhrawardy Med Coll 2022; 14(1): 12-15