Effects of Methotrexate on Prothrombin Time in Rheumatoid Arthritis Patients

Authors

  • Mst Shakila Parvin Assistant Professor, Department of Pharmacology & Therapeutics, Kushtia Medical College, Kushtia
  • Mamun Ur Rashid Professor, Department of Pharmacology & Therapeutics, Islami Bank Medical College, Rajshahi
  • Md Anwar Habib Professor, Department of Pharmacology & Therapeutics, Rajshahi Medical College, Rajshahi
  • Shahin Ara Associate Professor, Department of Pharmacology & Therapeutics, Rajshahi Medical College, Rajshahi

DOI:

https://doi.org/10.3329/kyamcj.v6i1.32779

Keywords:

Methotrexate, Prothrombin time, Rheumatoid arthritis

Abstract

The present study was undertaken to evaluate safety and efficacy of methotrexate in Rheumatoid arthritis patients. This study was carried out on ARA criteria fulfilling 35 diagnosed Rheumatoid arthritis patients of either gender, aged 20-60 years, presented in Medicine department of Rajshahi Medical College Hospital, Rajshahi from July 2007 to June 2008. Patients with normal liver function tests and HBsAg and anti-HCV negative cases were given oral methotrexate (10-15 mg/wk) for 6 weeks. Baseline prothrombin time was 12.97±0.34 seconds. After 6 weeks of methotrexate therapy prothrombin time was found 13.47±0.46 seconds. During methotrexate therapy change of prothrombin time was not significant (p>0.05).

KYAMC Journal Vol. 6, No.-1, Jul 2015, Page 550-552

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Author Biography

Mst Shakila Parvin, Assistant Professor, Department of Pharmacology & Therapeutics, Kushtia Medical College, Kushtia



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Published

2017-06-04

How to Cite

Parvin, M. S., Rashid, M. U., Habib, M. A., & Ara, S. (2017). Effects of Methotrexate on Prothrombin Time in Rheumatoid Arthritis Patients. KYAMC Journal, 6(1), 550–552. https://doi.org/10.3329/kyamcj.v6i1.32779

Issue

Vol. 6 No. 1 (2015)

Section

Original Articles