Effect of Low Dose Ketamine on Propofol Injection Pain: A Double-Blind Clinical Trial


  • Muhammad Sazzad Hossain Associate Professor and HOD, Anesthesiology, National Institute of ENT. Tejgaon, Dhaka, Bangladesh
  • Md Afzalur Rahman Junior consultant, Department of Anesthesiology. National Institute of ENT. Tejgaon, Dhaka, Bangladesh
  • Syed Ariful Islam Medical officer, National Institute of ENT. Tejgaon, Dhaka, Bangladesh
  • Sanzida Munira Postgraduate Trainee, Dhaka Dental College, Dhaka, Bangladesh
  • Mohammad Iftakhairul Hasan Medical Officer, Department of Anesthesia, Analgesia, Palliative and Intensive Care Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Muhammad Alamgir Mandal Associate Professor and HOD, Physical Medicine and Rehabilitation. TMSS Medical College Hospital, Bogura. Bangladesh




Ketamine, Propofol, Pain on propofol injection (POPI).


Background: Propofol, most frequently used intravenous anesthetic for induction of routine elective surgical procedure. Pain on propofol injection (POPI) still remains a considerable concern for the anesthesiologist. A number of techniques has been tried to minimize propofol-induced pain with variable results.

Objective: This study was performed to determine the effect of ketamine on reducing pain on propofol injection (POPI) at the onset of anesthesia.

Materials and Methods: A total of 80 adult healthy patients were selected in this study of either sex, scheduled for routine elective ENT surgery under general anesthesia. The patients enrolled were divided randomly into two groups of 40 patients each. Group I (ketamine group) received 10 mg intravenous ketamine in 10 ml normal saline. Group II (placebo group) received 10 ml of 0.9% intravenous normal saline. Then the patients were induced with propofol and asked to report their pain during injection of propofol and recorded according to the Mc Cririck and Hunter scale.

Results: The incidence of pain experienced in ketamine group was 10% patients and in saline group was 60% patients, which is statistically significant p<0.05. The severity of POPI was also lower in ketamine group than the saline group (p<0.05). The incidence of mild and moderate pain in ketamine group versus saline group was 7.5% versus 45% and 2.5% versus 15% respectively p<0.05. There was no severe pain recorded in any groups.

Conclusion:Intravenous ketamine in low dose before induction of general anesthesia can be effective medication in reducing pain on propofol injection.

KYAMC Journal Vol. 11, No.-2, July 2020, Page 96-99


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How to Cite

Hossain, M. S., Rahman, M. A., Islam, S. A., Munira, S., Hasan, M. I., & Mandal, M. A. (2020). Effect of Low Dose Ketamine on Propofol Injection Pain: A Double-Blind Clinical Trial. KYAMC Journal, 11(2), 96–99. https://doi.org/10.3329/kyamcj.v11i2.48423



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