Determination of the frequency of carbapenemase producing Klebsiella pneumoniae isolates in Dhaka city, Bangladesh

Authors

  • Nawshad Hayder Department of Microbiology, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka-1217 and Department of Microbiology, Ancillary Service, Square Hospital Ltd. 18/F, Bir Uttam Nooruzzaman Sarak, Pantha Path, Dhaka-1205
  • Zahidul Hasan Department of Microbiology, Ancillary Service, Square Hospital Ltd. 18/F, Bir Uttam Nooruzzaman Sarak, Pantha Path, Dhaka
  • Sadia Afrin Department of Microbiology, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka-1217 and Tuberculosis and Leprosy Department, International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka 1212
  • Rashed Noor Department of Microbiology, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka-1217

DOI:

https://doi.org/10.3329/sjm.v2i1.15210

Keywords:

Carbapenem, Klebsiella pneumoniae carbapenemase (KPC), multi-drug resistance

Abstract

Resistance of Klebsiella pneumoniae against carbapenem, imparted by the presence of carbapenemase, is an emerging global health problem with high morbidity and mortality. Thus, the present study attempted to detect the frequency of carbapenemase producing K. pneumoniae in Dhaka city of Bangladesh and thereby determine the health risk associated with their presence. A total of 647 K. pneumoniae isolates were detected from 2800 patients with urinary tract infection, bacterimia, wound infections and respiratory diseases. Thirty one carbapenem resistant isolates were found to harbor K. pneumoniae carbapenemase (KPC) through modified Hodge test. The KPC positive isolates were then subjected to the study of antibiogram and showed resistance against all the ß-lactam antibiotics along with carbapenems, while they were sensitive against colistin. Additionally, 287 isolates were found to be extended-spectrum ?-lactamases (ESBLs) positive apart from the KPC positive ones.

DOI: http://dx.doi.org/10.3329/sjm.v2i1.15210

Stamford Journal of Microbiology, Vol.2(1) 2012: 28-30

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Published

2013-06-04

How to Cite

Hayder, N., Hasan, Z., Afrin, S., & Noor, R. (2013). Determination of the frequency of carbapenemase producing Klebsiella pneumoniae isolates in Dhaka city, Bangladesh. Stamford Journal of Microbiology, 2(1), 28–30. https://doi.org/10.3329/sjm.v2i1.15210

Issue

Vol. 2 No. 1 (2012)

Section

Original Articles