Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of <i>Saccharum spontaneum</i> Linn.

Authors

  • Md Mynol Islam Vhuiyan Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh
  • Israt Jahan Biva Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh
  • Moni Rani Saha Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh
  • Muhammad Shahidul Islam Department of Pharmacy, Stamford University Bangladesh, 51, Siddeswari Road, Dhaka-1217, Bangladesh

DOI:

https://doi.org/10.3329/sjps.v1i1.1810

Keywords:

Saccharum spontaneum, Castor oil, Loperamide, Pentobarbitone

Abstract

Preliminary phytochemical screening of the methanolic extract of the whole plant of Saccharum spontaneum Linn. (Family- Gramineae) revealed the presence of alkaloids, flavonoids, reducing sugar, tannins and saponins. The antidiarrhoeal activity of the extract (200 and 400 mg/kg) was assessed on experimental animal and a dose dependent decrease in the total number of faecal dropping was obsereved in castor oil induced diarrhoea in mice. The plant extract was also assessed for effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract produced a dosedependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possesses antidiarrhoeal and CNS depressant activity.

Key Words: Saccharum spontaneum, Castor oil, Loperamide, Pentobarbitone.    

doi:10.3329/sjps.v1i1.1810

S. J. Pharm. Sci. 1(1&2): 63-68

Downloads

Download data is not yet available.
Abstract
240
PDF
187

Downloads

How to Cite

Vhuiyan, M. M. I., Biva, I. J., Saha, M. R., & Islam, M. S. (2009). Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of <i>Saccharum spontaneum</i> Linn. Stamford Journal of Pharmaceutical Sciences, 1(1), 63–68. https://doi.org/10.3329/sjps.v1i1.1810

Issue

Vol. 1 No. 1 (2008)

Section

Research Articles

License

As a condition of publication, all authors must transfer copyright to the Department of Pharmacy. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur in the submission, and that the final version of the manuscript has been seen and approved by them.

Each author must agree to this statement

Authorship: This manuscript is the original work of the authors, each of whom has read and approved of the work. Each author satisfied the requirements contained in 'Author Guidelines' having participated sufficiently in the work to take public responsibility for the content. This participation includes:

  • Conception or design of the study, or analysis and interpretation of data, or both
  • Drafting the article or revising it for critically important intellectual content
  • Approval of the final 'to be published' version

All authors must take responsibility for the integrity of the work. Participating solely in the collection of data does not justify authorship.

Prior publication: This work is not currently under consideration by any other journal. Information about prior publication of any part of this work, or inclusion of patients detailed herein in any other work, has been provided in the cover letter.

Conflict of interest: Details of any financial or other relationship between any author and any other party that may lead to a conflict of interest with the subject or any materials mentioned in this article have been disclosed in the cover letter.