The Effect of Manufacturing Methods and Different Shapes on the Release Pattern of Diclofenac Sodium Matrix Tablet
DOI:
https://doi.org/10.3329/sjps.v2i2.5828Keywords:
Matrix tablet, release pattern, direct compression, wet granulation, PEG 600, Kollidon SRAbstract
In the present study sustained release diclofenac sodium matrix tablets were prepared using Kollidon SRpolymer. Hydroxypropyl methylcellulose (HPMC 15 cps) and poly ethylene glycol (PEG-600) polymers
respectively were used in formulating tablets prepared by direct compression and wet granulation methods.
The polymers were used to explore the release pattern of the drug into the dissolution media. The tablets
were also prepared in various shapes (caplet oval, round oval and flat oval). A comparatively higher release
rate of drug was obtained from the polymer HPMC 15 cps at 10% concentration for directly compressed
matrix tablet than those containing 20% of HPMC after a definite period of time. In wet granulation process,
10% PEG-600 containing tablets showed a better release than those containing 20% PEG. The drug release
was also found to be sustained in case of wet granulation method than that of the direct compression method.
Again the caplet shaped tablets in case of direct compression method showed better release rate of drug than
those of the round oval and flat oval shaped tablets. Thus the result of this study shows that the proper
selection of the percentage of polymer and the suitable shape of tablet and proper manufacturing method can
provide a greater opportunity in designing sustained release dosage forms.
Key words: Matrix tablet; release pattern; direct compression; wet granulation; PEG 600; Kollidon SR.
DOI: 10.3329/sjps.v2i2.5828
Stamford Journal of Pharmaceutical Sciences Vol.2(2) 2009: 76-80
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