Formulation Development of Verapamil Hydrochloride Tablet by Effervescent Method

Authors

  • Abul Kalam Lutful Kabir Lecturer, Dept. of Pharmacy, Jagannath University, Dhaka
  • Naz Hasan Huda Department of Pharmacy, Stamford University Bangladesh, Dhaka
  • Yeakuty Marzan Jhanker Department of Pharmacy, The University of Asia Pacific Dhaka
  • Kamrunnahar Shamin Department of Pharmacy, Stamford University Bangladesh, Dhaka

DOI:

https://doi.org/10.3329/sjps.v3i1.6795

Keywords:

Effervescent method, Verapamil Hydrochloride, Dispersion time

Abstract

Fast disintegrating tablets of Verapamil Hydrochloride were designed to achieve increased absorption as well as quick onset of pharmacological action of the active ingredient with a view to enhance patient compliance by effervescent method. Different combinations and ratios of sodium bicarbonate, anhydrous citric acid, sodium starch glycolate, Micro-crystalline cellulose (MCC) and lactose were used in order to get optimum result. The prepared formulations were evaluated for hardness, friability, thickness, diameter, taste of the solution to be administered and in-vitro dispersion time. The acceptable dispersion time was achieved by using a combination of citric acid and sodium bi carbonate in the same amount along with sodium starch glycolate, micro-crystalline cellulose (MCC) & lactose. Acceptable taste of the solution to be administered was obtained with a combination of sucrose, aspartame and sodium saccharine.

Key words: Effervescent method; Verapamil Hydrochloride; Dispersion time

DOI: 10.3329/sjps.v3i1.6795

S. J. Pharm. Sci. 3(1): 34-37

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How to Cite

Kabir, A. K. L., Huda, N. H., Jhanker, Y. M., & Shamin, K. (2011). Formulation Development of Verapamil Hydrochloride Tablet by Effervescent Method. Stamford Journal of Pharmaceutical Sciences, 3(1), 34–37. https://doi.org/10.3329/sjps.v3i1.6795

Issue

Vol. 3 No. 1 (2010)

Section

Research Articles

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