CONCENTRATIONS OF ESTRADIOL-17ß (E2), PRO-?C, IR-INHIBIN (INH), INHIBIN A AND INHIBIN B IN FOLLICULAR FLUID OF THE GTCT AFFECTED OVARY

Abstract

To clarify the characteristic of follicular fluid in mares with granulose theca cell tumor (GTCT) 5 mares from five GTCT affected mares were obtained at the time of removal of affected ovary from different parts in Japan. The 9 ovaries from the 6 normal mares were obtained from the abattoir. The diameter of each follicle in the ovaries was measured and the follicles were classified according to the diameter. The concentration of estradiol -17 ß (E2), ir- INH, pro?-C and INH-A were significantly lower as compared with that of normal ovarian follicular fluid. But the average concentration of INH-B in affected animal was not significantly lower as compared with that of healthy ovarian follicular fluids. According to this study it seems that the large follicles in GTCT affected ovaries were not mature like a healthy follicle. As a result estradiol -17ß (E2), ir- INH, pro?-C and INH-A were significantly lower as compared with that of normal mares.