EFFECT OF NERIUM OLEANDER POISONING ON BLOOD OF MALE GUINEAPIGS

Authors

  • MGA Chowdhury Thana Livestock Office, Kotwaly, Chittagong, Bangladesh
  • Azizunnesa . Department of Medicine and Surgery, Chittagong Government Veterinary College, Pahartali, Chittagong, 4202, Bangladesh
  • MA Hossain Department of Parasitology and Pathology, Chittagong Government Veterinary College, Pahartali, Chittagong, 4202, Bangladesh.
  • Q Hasan Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh- 2202, Bangladesh

DOI:

https://doi.org/10.3329/bjvm.v3i1.11389

Keywords:

Haematological parameters, poisoning effects, Nerium oleander, guineapig

Abstract

Haematological changes were studied in 36 adult male guineapigs during the period from July to December 1994. These animals were divided into six equal groups (A to F), each group consisting of six animals. Each animal of group B to F was administered with a single oral dose of crude watery extract of sheath oleander @ 300, 450, 600, 750 and 900 mg / kg body weight, respectively, whereas animals of group A which served as control. After administration of crude watery extract of 1/2, 6 and 72 hours a significant increase of in total erythrocyte count (TEC), total leukocyte count (TLC) and haemoglobin (Hb). The maximum increase on TEC, TLC and Hb as 35, 51 and 14%, respectively, @ 750 mg / kg body weight at 6 hr of administration of crude watery extract and the minimum value of TEC, TLC and Hb as 16, 27 and 4%, respectively, with the dose rate of 300 mg / kg body weight at the same time. The elevated haematological parameters returned to normal level within 7 days of administration.

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Published

2012-07-23

Issue

Section

Laboratory Animal Medicine