Environmentally persistant toxicant arsenic affects uterus grossly and histologically
DOI:
https://doi.org/10.3329/bjvm.v11i1.13175Keywords:
Gross, Histology, Uterus, Arsenic, Black Bengal Goat, Persistant ToxicantAbstract
The experiment was carried out to determine the gross and microscopic effects of arsenic on uterus of female Black Bengal Goats against control group in the Department of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202. A total of twelve mature female Black Bengal goats were studied, six from arsenic affected areas of Mymensingh district and theother six from Hill Tracts of Bangaldesh which are arsenic free. Gross parameters show slight variations in the morphology (color and shape) and biometry (size and weight) of uterus of arsenic affected Black Bengal goats, but this variation was statistically insignificant (p>0.05). For microscopic study, permanent slide was prepared by Mayers Hematoxylin and Eosin stain method. In microscopic level, there were significant variations in arsenic affected group of goats compared to the control group. Arsenic affected group of goats show thickening of uterine horn (p<0.01), uterine gland is lower in amount and diameter(p<0.01), cervical villi length was smaller (p<0.01), cervical wall thickness was higher (p<0.01). This work may be the tip of the iceberg representing the full extent of arsenic exposure to female genital tract.
DOI: http://dx.doi.org/10.3329/bjvm.v11i1.13175
Bangl. J. Vet. Med. (2013). 11 (1): 61-68
Downloads
159
118
References
REFERENCES
Akram Z, Jalali S, Shami SA, Ahmad L, Batool S and Kalsoon O (2009). Adverse effects of arsenic exposure on uterine function and structure in female rat. Experimental and Toxicologic Patohology 61: 415-530
ATSDR (Agency for Toxic Substances and Disease Registry (2005). Toxicological Profile for Arsenic (Draft for Public Comment). Department of Health and Human Services, Public Health Service. Atlanta, GA: U.S. Available at: http://www.atsdr.cdc.gov/toxprofiles/phs2.html
Bode AM and Dong Z (2002). The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects. Crit Rev Oncol Hematol, 42: 524.
Chakraborti D, Rahman MM, Das B, Murrill M, Dey S, Mukherjee SC, Dhar RK, Biswas BK, Chowdhury UK, Roy S, Sorif S, Selim M, Rahman M and Q Quamruzzaman (2010). Status of groundwater arsenic contamination in Bangladesh: A 14-year study report. Water Res, 44(19): 5789-5802. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20684969.
DLS (2012). nual Report of Department of Livestock ServiceAns: 2012. http://www.dls.gov.bd
DPHE (Department of Public Health Engineering) (2009) Handbook on Arsenic Pollution of Bangladesh. Mymensing District, Bangladesh. pp 127-142
FAO (1997). FAO Production Year Book. FAO of the United Nations. Rome, Italy. Vol. 51, pp: 108-111.
Friberg L, Nordberg GF and Vook VB (1986). Handbook on the Toxicology of Metals, 2nd ed, Elsevier Science Publisher, Amsterdam, New York, Vol. II, pp. 43-83.
Goering PL, Aposhian HV, Mass MJ, Cebrian M, Beck BD and Waalkes MP. (1999). The enigma of arsenic carcinogenesis: Role of metabolism. Toxicol Sci, 49: 514.
Gridley MF (1960). Manual of Histologic and Special Staining Technique. McGraw-Hill Book Company, New York, NY. pp. 28-29 and 82-83.
Hossain MF (2006). Arsenic contamination in Bangladeshan overview. Agr Ecosyst Environ, 113(1-4): 1-16.
Islam MA, Zaman MW, Shamsuddoha ATM, Haque FMA and Molla MOG (2005). Effect of long term groundwater irrigation on fertility status of surface soils in Nijhuri series under high barind tract. International Journal of Sustainable Agricultural Technology. 2005; 1(6): 49-54
Islam MT, Parvin S, Pervin M, Bari ASM and Khan MAHNA (2011). Effects of chronic arsenic toxicity on the haematology and histoarchitecture of female reproductive system of Black Bengal Goat. Bangl. J. Vet. Med. (2011). 9(1):59-66
Khan MMH, Aklimunnessa K, Kabir M and Mori M (2006). Case-control study of arsenicosis in some arsenic contaminated villages of Bangladesh. Sapporo Med J, 75: 51-61.
Kile ML, Houseman EA, Breton CV, Smith T, Quamruzzaman Q, Rahman M, Mahiuddin G and Christiani DC (2007). Dietary arsenic exposure in Bangladesh. Environ Health Perspect, 115(6): 889893.
Luna LG (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd edn. McGraw Hill Book Co. New York, USA.
Morand-Fehr and Boyazoghu (1999). Animal Distribution records. Abstract 30: 2540p.
Naidu R, Smith E, Owens G, Akter K, Khan NI, Huq I and Rahman M (2006). Potential arsenic exposure pathways in Bangladesh. Paper Presented at 6th International Conference on "Safe Water and Safe Food Options in Arsenic Mitigation: Lesson Learnt", held at 4 5 January, 2006, Dhaka, Bangladesh.
Neumann RB, Ashfaque KN, Badruzzaman ABM, Ali MA, Shoemaker JK and Harvey CF. (2010). Anthropogenic influences on groundwater arsenic concentrations in Bangladesh. Nature Geoscience, 3: 4652.
Sandip-Chattopadhyay, Pal S, Ghosh D and Debnath J (2003). Effect of dietary co-administration of sodium selenite on sodium arsenite-induced ovarian and uterine disorders in mature albino rats. Toxicological-Sciences. 2003; 75(2): 412-422.
Smith AH, Lingas EO and Rahman M. (2000). Contamination of drinking-water by arsenic in Bangladesh: A public health emergency. Bull WHO, 78: 1093-1103.
Thomas DJ, M Styblo and Lin S (2001). The cellular metabolism and systemic toxicity of arsenic. Toxicol Appl Pharmacol, 176: 127144.
US EPA (1985). Ambient Water Quality Criteria for Arsenic. US Environ Protection Agency. Rep. 440/5-84-033, pp. 66.
Wahidur R (2006). Arsenic Exposure in Bangladesh: The Reproductive and Developmental Health Effects in Humans. Philadelphia Annual Meeting held on 2225 October, 2006. Paper No. 67-73
Waxman S and Anderson KC (2001). History of the development of arsenic derivatives in cancer therapy. The Oncologist, 6: 3-10.
WHO (World Health Organization). (2004). Water Sanitation and Health. Geneva, World Health Organization.
Yih L, Peck K and Lee T. (2002). Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis, 23: 867876.
Zeuner FE (1963). History of domestic animals. London, U.K, Hulchinson and Co. Ltd. Animal Breeding Abstract 31:2641p.
Zhang C, Ling B, Liu J and Wang G (2003). Toxic effect of fluoride-arsenic on the reproduction and development of rats. Fluoride. 2003; 36(2): 137
