Effect of certain haematinics on body weight and haemato-biochemical changes in laboratory mice

Abstract

A total of 24, six weeks old mice were used to study the body weight and haemato-biochemical changes following administering of different haematinics (CuSO₄, FeSO₄ and Vitamin B₁₂). The experiment was performed in Physiology laboratory, Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, from February to March 2006. They were randomly assigned to one of four equal groups (n = 6). In addition to normal rat pellets Group A was supplemented with CuSO₄ @ 0.6mg/mice/day orally, Group B with FeSO₄ @ 1.2mg/mice/day orally, and Group C with Vitamin B₁₂ (Cytamin^®, Glaxo) @ 0.004mg/mice intramuscularly at every 7 days. Group D was considered as control and was also supplemented with rat pellets. Increased body weight was observed in all haematinic treated mice but group B had a significant (p < 0.05) higher weight gain compared to the control. TEC and PCV increased significantly (p < 0.05) in all the treatment groups compared to the control. Statistically insignificant (p > 0.05) increase in TLC was also recorded in all the treated groups. Hb concentration increased for all the treatment groups. The ESR values of the experimental mice were negligible in first hour. The serum transaminases (SGPT and SGOT) increased in all treated groups but the difference in group A was significant (p < 0.05) compared to the control. Blood urea was recorded significantly (P < 0.01) higher for group A and lower for group C compared to the control. This study can be helpful to study the effect of particular haematinic on animal especially on simple stomach animal and human being as mice is used as human and animal model.

Key words: Haematinics, haemato-biochemical parameters, mice

DOI = 10.3329/bjvm.v5i1.1325

Bangl. J. Vet. Med. (2007). 5 (1 & 2): 103-105