HYPOLIPIDEMIC EFFECT OF GINGER EXTRACT IN VANASPATI FED RATS
Keywords:Vanaspati, ginger, hypolipidemic, rat
The aim of the present study was to evaluate the hypolipidemic effect of ginger in vanaspati fed rats. A total of 18 rats of Long Evans strain weighing 200-250 g were randomly assigned to three groups: Group I, normal control; Group II, 5% vanaspati supplement and Group III, 5% vanaspati + ginger extract (300 mg/ 100ml/ kg b. wt./ day) orally. Serum lipid profile was measured at day 1st and day 49th. The administration of vanaspati augmented the total cholesterol, LDL-C, triglycerides levels and decreased the HDL-C level significantly (p <0.05). Simultaneous administration of ginger extract significantly (p <0.05) prevented the rise in total cholesterol, LDL-C(bad cholesterol), triglycerides levels and rise HDL(good cholesterol). In histopathological study, no significant changes were found in the liver and aorta of all treated groups as compared with control group. It is concluded that ginger extract showed hypolipidemic effect in vanaspati supplemented rats.