Comparative Serological Responses and Protection Conferred by Vaccination with V₄HR and BCRDV in Chickens

Abstract

The serological responses and protection of Sonali breed chickens with Australian Newcastle disease V₄ heat resistant (NDV₄HR) live freeze-dried vaccine (Australian Webster Pvt. Ltd., Sydney) was compared with that of locally produced conventional Lentogenic F-strain Baby Chick Ranikhet Disease vaccine (BCRDV, DLS, Dhaka) of Bangladesh. Thirty day-old chicks were purchased from Mirpur Govt. Poultry Farm, Dhaka and maintained hygienically with commercial feed and water supply ad libitum during the experimental period from November 2002 to January 2003. These birds were divided into three groups (A, B and C), each consisting of 10 birds. Each birds of group A was vaccinated with NDV₄HR and group B with BCRDV intraocularly, primary vaccination at 7 days and booster vaccination at 28 days of age, whereas the birds of group C kept as control. Sera samples of each of the bird of all the three groups were collected at 14 days of post-vaccination following each of the primary and booster vaccination at 23 and 44 days of age of birds. Each of the serum sample of all the three groups of birds was titrated by using haemagglutination inhibition (HI) test and results recorded that both the NDV₄HR (32.49 ± 23.94) and BCRDV (28.28 ± 10.54) produced more or less similar serological response at two weeks after booster vaccination. The results of challenged experiment showed that the NDV₄HR vaccine ( 80% ) apparently conferred higher protection to birds than the BCRDV vaccine (70%). Therefore both the vaccines may be recommended to control ND in commercial chickens but NDV₄HR vaccine could provide a practical method of control ND in rural scavenging chickens.

Key words: Serological responses, F-strain (BCRDV) NDV₄HR vaccine, HI antibody titre, protection, chickens

DOI = 10.3329/bjvm.v1i1.1913

Bangl. J. Vet. Med. ( 2003 ). 1 (1) : 25 - 27